Publications

Bachmann, F., Duthaler, U., Meyer Zu Schwabedissen, H. E., Puchkov, M., Huwyler, J., Haschke, M. and Krähenbühl, S. (2021) “Metamizole is a Moderate Cytochrome P450 Inducer Via the Constitutive Androstane Receptor and a Weak Inhibitor of CYP1A2”, Clinical Pharmacology and Therapeutics. Wiley, 109(6), pp. 1505–1516. doi: 10.1002/cpt.2141.   edoc
Wagner-Hattler, L., Kiene, K., Bielicki, J., Pfister, M., Puchkov, M. and Huwyler, J. (2021) “High Acceptability of an Orally Dispersible Tablet Formulation by Children”, Children. MDPI, 8(3), p. 194. doi: 10.3390/children8030194.   edoc
Einfalt, T., Detampel, P., Häussinger, D., Casper, J., Meier, C., Puchkov, M. and Huwyler, J. (2021) “Hydroxychloroquine immediate release tablets: Formulation and evaluation of a solid dosage form”, ChemRxiv Preprint. doi: 10.26434/chemrxiv.14170508.v1.   edoc | Open Access
Schreiner, V., Detampel, P., Jirkof, P., Puchkov, M. and Huwyler, J. (2021) “Buprenorphine loaded PLGA microparticles: Characterization of a sustained-release formulation”, Journal of Drug Delivery Science and Technology, 63, p. 102558. doi: 10.1016/j.jddst.2021.102558.
Schittny, A., Waldner, S., Duthaler, U., Vorobyev, A., Abramovich, R., Krähenbühl, S., Puchkov, M. and Huwyler, J. (2021) “Particle Forming Amorphous Solid Dispersions: A Mechanistic Randomized Pharmacokinetic Study in Humans”, pharmaceutics, 13(401), pp. 1–17. doi: 10.3390/pharmaceutics13030401.
Schittny, A., Huwyler, J. and Puchkov, M. (2020) “Mechanisms of increased bioavailability through amorphous solid dispersions: a review”, Drug delivery. Taylor and Francis, 27(1), pp. 110–127. doi: 10.1080/10717544.2019.1704940.   edoc
Suenderhauf, C., Berger, B., Puchkov, M., Schmid, Y., Müller, S., Huwyler, J., Haschke, M., Krähenbühl, S. and Duthaler, U. (2020) “Pharmacokinetics and phenotyping properties of the ‘Basel’ phenotyping cocktail combination capsule in healthy male adults”, British journal of clinical pharmacology. Wiley, 86(2), pp. 352–361. doi: 10.1111/bcp.14157.   edoc
Wagner-Hattler, L., Québatte, G., Keiser, J., Schoelkopf, J., Schlepütz, C. M., Huwyler, J. and Puchkov, M. (2020) “Study of drug particle distributions within mini-tables using synchrotron X-ray microtomography and superpixel image clustering”, International Journal of Pharmaceutics. Elsevier, 573, p. 118827. doi: 10.1016/j.ijpharm.2019.118827.   edoc
Farzan, M., Québatte, G., Strittmatter, K., Hilty, F. M., Schoelkopf, J., Huwyler, J. and Puchkov, M. (2020) “Spontaneous In Situ Formation of Liposomes from Inert Porous Microparticles for Oral Drug Delivery”, pharmaceutics, 12(777), pp. 1–17. doi: 10.3390/pharmaceutics12080777.
Cörek, E., Rodgers, G., Siegrist, S., Einfalt, T., Detampel, P., Schlepütz, C. M., Sieber, S., Fluder, P., Schulz, G., Unterweger, H., Alexiou, C., Müller, B., Puchkov, M. and Huwyler, J. (2020) “Shedding Light on Metal-Based Nanoparticles in Zebrafish by Computed Tomography with Micrometer Resolution”, Small, 2000746, pp. 1–10. doi: 10.1002/smll.202000746.
Yokoyama, R., Kimura, G., Huwyler, J., Hosoya, K.- ichi and Puchkov, M. (2020) “Impact of Insoluble Separation Layer Mechanical Properties on Disintegration and Dissolution Kinetics of Multilayer Tablets”, pharmaceutics, 12(495), p. 12060495. doi: 10.3390/pharmaceutics12060495.
Schittny, A., Philipp-Bauer, S., Detampel, P., Huwyler, J. and Puchkov, M. (2020) “Mechanistic insights into effect of surfactants on oral bioavailability of amorphous solid dispersions”, Journal of controlled release, 320, pp. 214–225. doi: 10.1016/j.jconrel.2020.01.031.
Farzan, M., Roth, R., Québatte, G., Schoelkopf, J., Huwyler, J. and Puchkov, M. (2019) “Loading of Porous Functionalized Calcium Carbonate Microparticles: Distribution Analysis with Focused Ion Beam Electron Microscopy and Mercury Porosimetry”, Pharmaceutics. MDPI, 11(1), p. 32- . doi: 10.3390/pharmaceutics11010032.   edoc
Yokoyama, R., Kimura, G., Schlepütz, C. M., Huwyler, J. and Puchkov, M. (2018) “Modeling of Disintegration and Dissolution Behavior of Mefenamic Acid Formulation Using Numeric Solution of Noyes-Whitney Equation with Cellular Automata on Microtomographic and Algorithmically Generated Surfaces”, Pharmaceutics. MDPI, 10(4), p. 259. doi: 10.3390/pharmaceutics10040259.   edoc | Open Access
Wimmersberger, D., Coulibaly, J. T., Schulz, J. D., Puchkov, M., Huwyler, J., N’Gbesso, Y., Hattendorf, J. and Keiser, J. (2018) “Efficacy and Safety of Ivermectin Against Trichuris trichiura in Preschool-aged and School-aged Children: A Randomized Controlled Dose-finding Trial”, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 67(8), pp. 1247–1255. doi: 10.1093/cid/ciy246.   edoc
Wagner-Hattler, L., Schoelkopf, J., Huwyler, J. and Puchkov, M. (2018) “Stability investigation of FCC-based tablets for oral suspension with caffeine and oxantel pamoate as model drugs”, Drug development and industrial pharmacy, pp. 1–9. doi: 10.1080/03639045.2018.1529784.   edoc
Schittny, A., Ogawa, H., Huwyler, J. and Puchkov, M. (2018) “A Combined Mathematical Model Linking the Formation of Amorphous Solid Dispersions with Hot-Melt-Extrusion Process Parameters”, European Journal of Pharmaceutics and Biopharmaceutics. Elsevier, 132, pp. 127–145. doi: 10.1016/j.ejpb.2018.09.011.   edoc
Moser, W., Sayasone, S., Xayavong, S., Bounheuang, B., Puchkov, M., Huwyler, J., Hattendorf, J. and Keiser, J. (2018) “Efficacy and tolerability of triple drug therapy with albendazole, pyrantel pamoate, and oxantel pamoate compared with albendazole plus oxantel pamoate, pyrantel pamoate plus oxantel pamoate, and mebendazole plus pyrantel pamoate and oxantel pamoate against hookworm infections in school-aged children in Laos : a randomised, single-blind trial”, The Lancet infectious diseases. Elsevier, 18(7), pp. 729–737. doi: 10.1016/S1473-3099(18)30220-2.   edoc
Barda, B., Ame, S. M., Ali, S. M., Albonico, M., Puchkov, M., Huwyler, J., Hattendorf, J. and Keiser, J. (2018) “Efficacy and tolerability of moxidectin alone and in co-administration with albendazole and tribendimidine versus albendazole plus oxantel pamoate against Trichuris trichiura infections : a randomised, non-inferiority, single-blind trial”, The Lancet infectious diseases. Elsevier, 18(8), pp. 864–873. doi: 10.1016/S1473-3099(18)30233-0.   edoc
Roth, R., Schoelkopf, J., Huwyler, J. and Puchkov, M. (2018) “Functionalized calcium carbonate microparticles for the delivery of proteins”., European Journal of Pharmaceutics and Biopharmaceutics, 122, pp. 96–103. doi: 10.1016/j.ejpb.2017.10.012.   edoc
Barda, B., Sayasone, S., Phongluxa, K., Xayavong, S., Keoduangsy, K., Odermatt, P., Puchkov, M., Huwyler, J., Hattendorf, J. and Keiser, J. (2017) “Efficacy of Moxidectin Versus Ivermectin Against Strongyloides stercoralis Infections: A Randomized, Controlled Noninferiority Trial”, Clinical Infectious Diseases. Oxford University Press, 65(2), pp. 276–281. doi: 10.1093/cid/cix278.   edoc
Wagner-Hattler, L., Wyss, K., Schoelkopf, J., Huwyler, J. and Puchkov, M. (2017) “In vitro characterization and mouthfeel study of functionalized calcium carbonate in orally disintegrating tablets”, International Journal of Pharmaceutics. Elsevier, 534, pp. 50–59. doi: 10.1016/j.ijpharm.2017.10.009.   edoc
Moser, W., Coulibaly, J., Ali, S. M., Ame, S. M., Amour, A. K., Yapi, R. B., Albonico, M., Puchkov, M., Huwyler, J., Hattendorf, J. and Keiser, J. (2017) “Efficacy and safety of tribendimidine, tribendimidine plus ivermectin, tribendimidine plus oxantel pamoate, and albendazole plus oxantel pamoate against hookworm and concomitant soil-transmitted helminth infections in Tanzania and Côte d’Ivoire: a randomised, controlled, single-blinded, non-inferiority trial”, Lancet Infectious Diseases. Elsevier, 17(11), pp. 1162–1171. doi: 10.1016/S1473-3099(17)30487-5.   edoc
Wagner-Hattler, L., Schoelkopf, J., Huwyler, J. and Puchkov, M. (2017) “Characterization of new Functionalized Calcium Carbonate-Polycaprolactone Composite Material for Application in Geometry-constrained Drug Release Formulation Development”, Drug Development and Industrial Pharmacy. Taylor & Francis, 43(10), pp. 1669–1676. doi: 10.1080/03639045.2017.1328435.   edoc
Preisig, D., Roth, R., Tognola, S., Varum, F. J. O., Bravo, R., Cetinkaya, Y., Huwyler, J. and Puchkov, M. (2016) “Mucoadhesive microparticles for local treatment of gastrointestinal diseases”, European journal of pharmaceutics and biopharmaceutics. Elsevier, 105, pp. 156–165. doi: 10.1016/j.ejpb.2016.06.009.   edoc
Eberle, V. A., Häring, A., Schoelkopf, J., Gane, P. A. C., Huwyler, J. and Puchkov, M. (2016) “In silico and in vitro methods to optimize the performance of experimental gastroretentive floating mini-tablets”, Drug development and industrial pharmacy. Informa Healthcare, 42(5), pp. 808–817. doi: 10.3109/03639045.2015.1078350.   edoc
Camblin, M., Berger, B., Haschke, M., Krähenbühl, S., Huwyler, J. and Puchkov, M. (2016) “CombiCap: A novel drug formulation for the basel phenotyping cocktail”, International Journal of Pharmaceutics. Elsevier, 512(1), pp. 253–261. doi: 10.1016/j.ijpharm.2016.08.043.   edoc
Barda, B., Coulibaly, J. T., Puchkov, M., Huwyler, J., Hattendorf, J. and Keiser, J. (2016) “Efficacy and safety of moxidectin, synriam, synriam-praziquantel versus praziquantel against schistosoma haematobium and S. mansoni infections: a randomized, exploratory phase 2 trial”, PLoS Neglected Tropical Diseases. Public Library of Science, 10(9), p. e0005008. doi: 10.1371/journal.pntd.0005008.   edoc | Open Access
Preisig, D., Weingartner, M., Varum, F. J. O., Bravo, R., Alles, R., Huwyler, J. and Puchkov, M. (2015) “Marker-ion analysis for quantification of mucoadhesivity of microparticles in particle-retention assays”, International journal of pharmaceutics. Elsevier, 487(1-2), pp. 157–166. doi: 10.1016/j.ijpharm.2015.04.020.   edoc
Eberle, V. A., Donzelli, M., Alles, R., Puchkov, M. and Huwyler, J. (2015) “In Vivo Evaluation of a Gastroretentive Drug Delivery System Based on Enteric-Coated Floating Tablets”, Clinical Research: Open Access. SciForschen, 1.2. doi: 10.16966/2469-6714.105.   edoc | Open Access
Moser, W., Ali, S. M., Ame, S. M., Speich, B., Puchkov, M., Huwyler, J., Albonico, M., Hattendorf, J. and Keiser, J. (2015) “Efficacy and safety of oxantel pamoate in school-aged children infected with Trichuris trichiura on Pemba Island, Tanzania: a parallel, randomised, controlled, dose-ranging study”, The Lancet infectious diseases. Elsevier, 16(1), pp. 53–60. doi: 10.1016/S1473-3099(15)00271-6.   edoc
Stirnimann, T., Di Maiuta, N., Gerard, D. E., Alles, R., Huwyler, J. and Puchkov, M. (2013) “Functionalized Calcium Carbonate as a Novel Pharmaceutical Excipient for the Preparation of Orally Dispersible Tablets”, Pharmaceutical research. Plenum Press, Vol. 30, H. 7, pp. 1915–1925. doi: 10.1007/s11095-013-1034-3.   edoc
Kimura, G., Puchkov, M. and Leuenberger, H. (2013) “An attempt to calculate in silico disintegration time of tablets containing mefenamic acid, a low water-soluble drug”, Journal of pharmaceutical sciences. American Pharmaceutical Association, Vol. 102, H. 7, pp. 2166–2178. doi: 10.1002/jps.23541.   edoc
Nalluri, V. R., Puchkov, M. and Kuentz, M. (2013) “Toward better understanding of powder avalanching and shear cell parameters of drug-excipient blends to design minimal weight variability into pharmaceutical capsules”, International journal of pharmaceutics. Elsevier, Vol. 442, H. 1-2, pp. 49–56. doi: 10.1016/j.ijpharm.2012.08.010.   edoc
Leuenberger, H., Leuenberger, M. and Puchkov, M. (2011) “Virtual scale-up of manufacturing solid dosage forms”, in Pharmaceutical process scale-up. New York: Informa Healthcare (Drugs and the pharmaceutical sciences), p. 490.   edoc
Hans Leuenberger, M. P. and Etienne Krausbauer, G. B. (2009) “Manufacturing Pharmaceutical Granules : Is the Granulation Endpoint a Myth?”, Powder technology. Elsevier Science, Vol. 189, pp. 141–148.   edoc
Krausbauer, E., Puchkov, M., Betz, G. and Leuenberger, H. (2008) “Rational estimation of the optimum amount of non-fibrous disintegrant applying percolation theory for binary fast disintegrating formulation”, Journal of pharmaceutical sciences. American Pharmaceutical Association, Vol. 97, H. 1, pp. 529–541. doi: 10.1002/jps.21163.   edoc
Kimura, G., Puchkov, M., Betz, G. and Leuenberger, H. (2007) “Percolation theory and the role of maize starch as a disintegrant for a low water-soluble drug”, Pharmaceutical development and technology. Marcel Dekker, Vol. 12, H. 1, pp. 11–19. doi: 10.1080/10837450601166494.   edoc
Leuenberger, H., Plitzko, M. and Puchkov, M. (2006) “Spray freeze drying in a fluidized bed at normal and low pressure”, Drying technology. Taylor & Francis, Vol. 24, H. 6, pp. 711–719. doi: 10.1080/07373930600684932.   edoc
Leuenberger, H., Menshutina, N., Betz, G. and Puchkov, M. N. (2006) “E-learning and development of new courses and scientific work in the field of pharmaceutical technology”, Chimia. Schweizerische Chemische Gesellschaft, 60(1-2), pp. 80–82. doi: 10.2533/000942906777675209.   edoc | Open Access