Riccardo Mancuso graduated in the MSc Biotechnology in 2011 at the University of Palermo, Italy. During his studies, he carried out his master thesis with an Erasmus fellowship at the Chemistry and Bioanalytics Laboratory of the School of Life Sciences FHNW in Basel, Switzerland, where he worked on the establishment of highly efficient transfection protocols for recombinant protein production in HEK293 and CHO cell lines, under the guidance of Dr. Ronald Tynes. Before starting his PhD studies, he worked at Chemistry and Bioanalytics Laboratory of the School of Life Sciences FHNW.
He did his PhD studies from 2013-2016 in the group of Prof. Stephan Krähenbühl at the Department of Clinical Pharmacology & Toxicology, University Hospital of Basel, where he continued his investigations as post-doctoral fellow. His project is in close cooperation with the company AlloCyte Pharmaceuticals AG.
He joined the research group of Molecular Pharmacy in July 2020 as an associated group member. His work is focused on the discovery and pre-clinical development of novel integrin inhibitors.
Zhou, X., Bouitbir, J., Liechti, M. E., Krähenbühl, S., Mancuso, R. V. (2020) «Para-halogenation of amphetamine and methcathinone increases the mitochondrial toxicity in undifferentiated and differentiated SH-SY5Y cells», International Journal of Molecular Sciences, 21(8), 2841. doi: 10.3390/ijms21082841.
Zhou, X., Bouitbir, J., Liechti, M. E., Krähenbühl, S., Mancuso, R. V. (2020) «Hyperthermia increases the methcathinone-induced neurotoxicity», Cells, 9(4), 965. doi: 10.3390/cells9040965.
Mancuso, R.V., Casper, J., Schmidt, A.G., Krähenbühl, S., Weitz-Schmidt, G. (2020) «Anti-αLβ2 antibodies reveal novel endocytotic crossmodulatory functionality», British Journal of Pharmacology 177(12), 2696-2711. doi: 10.1111/bph.14996.
Mancuso, R.V., Welzenbach, K., Steinberger, P., Krähenbühl, S., Weitz-Schmidt, G. (2016) «Downstream effect profiles discern different mechanisms of integrin αLβ2 inhibition» Biochemical Pharmacology 119, 42-55. doi: 10.1016/j.bcp.2016.09.002.
Welzenbach, K., Mancuso, R.V., Steinberger, P., Krähenbühl, S., Weitz-Schmidt, G. (2015) «A novel multi-parameter assay to dissect the pharmacological effects of different modes of integrin αLβ2 inhibition in whole blood» British Journal of Pharmacology 172(20), 42-55. doi: 10.1111/bph.13256.