Aktuelle Masterarbeitsthemen der Forschungsgruppe Klinische Pharmakologie & Toxikologie
Current Master's Theses-Projects of the Research Group in Clinical Pharmacology & Toxicology
|MSc Pharmazie||MSc Drug Sciences||Bemerkungen|
|Einfluss einer Anti-IL-5 Antikörpertherapie auf die kutane Entzündung bei bullösem Pemphigoid (mit Labor)||Prof. Hans-Uwe Simon||ja||ja|
|Die Expression von Autophagie-regulierenden Proteinen bei malignen Tumorerkrankungen (mit Labor)||Prof. Hans-Uwe Simon||ja||ja|
|Mitophagy and mitochondrial dynamics in human skin-derived stem cells (mit Labor)||Prof. Hans-Uwe Simon|
|Masterarbeit im Bereich Analytik (LC-MS) in Bern (mit Labor)||Prof. Manuel Haschke||ja||ja|
|Contribution of mTORC2 to simvastatin-induced myotoxicity and insulin resistance in mice||nein||ja|
|Mechanisms of myotoxicity associated with Tyrosine Kinase Inhibitors||PD Dr. Jamal Bouitbir||nein||ja|
|Interaction of substituted cathinones related to MDPV andpyrovalerone with the monoamine transporters in vitro|
Project Description and aim:
New psychoactive substances (NPS) known on the drug market as “legal highs”, “bath salts” or “research chemicals” constantly emerge on the recreational drug market. These substances can be of novel origin or recently on the market. Their consumption poses great risks to users and global health (i.e acute or long-term toxic events). Since relatively little is known about incoming NPS in terms of their potential toxicological and psychopharmacological properties, in our laboratory, we investigate and characterize such substances in vitro.
The student will work under the supervision of Karolina Kolaczynska (PhD student) at the Psychopharmacology laboratory in the Department of Biomedicine (DBM). The focus of the research will be to investigate and characterize 14 different substituted cathinones (NPS) related to MDPV and pyrovalerone in vitro. The master student will investigate how these substances interact with the three monoamine uptake transporters, using human embryonic kidney (HEK) 293 cell line which overexpresses the norepinephrine, dopamine and serotonin transporters. Furthermore, the acute toxicological profile of these substances will be determined.
Working Location: Lab 410, Department of Biomedicine (DBM), Hebelstrasse 20, 4031 Basel
Supervisor in charge: Professor Matthias Liechti
Project Time: Summer/Fall semester 2019
Students will need to be:
Establishment and validation of a Mannan-induced psoriasis arthritis-like disease model in mice
Goal: Psoriasis (Ps) and psoriasis arthritis (PsA) are chronic, autoimmune inflammatory diseases. Both genetic and environmental factors contribute to the onset and severity of these disorders. The mouse model of Mannan-induced psoriasis arthritis is IL-17A dependent and induces inflammation of joints and skin lesions, which resemble the human disease (Khmaladze I et al., PMID: 25136095). At Idorsia, we are working in an in vivo immunology pharmacology laboratory and this model would be of high interest to evaluate the efficacy and mechanism of actions of in house-developed compounds. The candidate tasks would be to establish and characterize the previously described model, to validate the model with reference compounds, and in parallel to assess the efficacy of Idorsia compounds. If time permits, the candidate would also validate and optimize additional efficacy models in the lab to improve the in vivo characterization of Idorsia compounds.
Working location: Idorsia Pharmaceuticals Ltd, Hegenheimermattweg 91, 4123 Allschwil
At Idorsia: Master Thesis supervisor (Leiter der Arbeit im Labor): Dr. Marianne Martinic, PhD (email@example.com), Director, Group Leader Immunology and Pharmacolgy; Direct supervisors: Anna Sassi and Jeremy Scherer (firstname.lastname@example.org, email@example.com)