Aktuelle Masterarbeitsthemen der Forschungsgruppe Klinische Pharmakologie & Toxikologie
Current Master's Theses-Projects of the Research Group in Clinical Pharmacology & Toxicology

 

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MSc PharmazieMSc Drug SciencesBemerkungen
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Einfluss einer Anti-IL-5 Antikörpertherapie auf die kutane Entzündung bei bullösem Pemphigoid (mit Labor)Prof. Hans-Uwe Simonjaja
Die Expression von Autophagie-regulierenden Proteinen bei malignen Tumorerkrankungen (mit Labor)Prof. Hans-Uwe Simonjaja
Mitophagy and mitochondrial dynamics in human skin-derived stem cells (mit Labor)Prof. Hans-Uwe Simon
Masterarbeit im Bereich Analytik (LC-MS) in Bern (mit Labor)Prof. Manuel Haschkejaja
Contribution of mTORC2 to simvastatin-induced myotoxicity and insulin resistance in mice

PD Dr. Jamal Bouitbir

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Mechanisms of myotoxicity associated with Tyrosine Kinase InhibitorsPD Dr. Jamal Bouitbir
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Interaction of substituted cathinones related to MDPV andpyrovalerone with the monoamine transporters in vitro

Project Description and aim:

New psychoactive substances (NPS) known on the drug market as “legal highs”, “bath salts” or “research chemicals” constantly emerge on the recreational drug market. These substances can be of novel origin or recently on the market. Their consumption poses great risks to users and global health (i.e acute or long-term toxic events). Since relatively little is known about incoming NPS in terms of their potential toxicological and psychopharmacological properties, in our laboratory, we investigate and characterize such substances in vitro.

The student will work under the supervision of Karolina Kolaczynska (PhD student) at the Psychopharmacology laboratory in the Department of Biomedicine (DBM).  The focus of the research will be to investigate and characterize 14 different substituted cathinones (NPS) related to MDPV and pyrovalerone in vitro. The master student will investigate how these substances interact with the three monoamine uptake transporters, using human embryonic kidney (HEK) 293 cell line which overexpresses the norepinephrine, dopamine and serotonin transporters. Furthermore, the acute toxicological profile of these substances will be determined.

Working Location: Lab 410, Department of Biomedicine (DBM), Hebelstrasse 20, 4031 Basel

Supervisor in charge: Professor Matthias Liechti

Project Time: Summer/Fall semester 2019

Students will need to be:

  • master student in pharmaceutical sciences

  • highly motivated and organized

  • interested in psychopharmacology and new psychoactive substances (NPS) 

Prof. Matthias Liechti
karolina.kolaczynska@unibas.ch

 

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Interaction of novel stimulants with the monoamine transporters in vitro

The student will work under the supervision of Dr Michael Baumann at the Designer Drug Research Unit (Baltimore, Maryland, US). The focus of the research will be to investigate dopamine, serotonin and noradrenaline trans-porter inhibition potencies of novel psychoactive substances (NPS) (mainly
stimulants) in rat brain synaptosomes. As a result, the student will assess the uptake inhibition of the compounds of interest in vitro.

The project will be supervised and examined in Basel ath the University of Basel by Prof. Matthias Liechti (Psychopharmacology Research at the DBM.

Prof. Matthias Liechtijaja

Establishment and validation of a Mannan-induced psoriasis arthritis-like disease model in mice 

Goal: Psoriasis (Ps) and psoriasis arthritis (PsA) are chronic, autoimmune inflammatory diseases. Both genetic and environmental factors contribute to the onset and severity of these disorders. The mouse model of Mannan-induced psoriasis arthritis is IL-17A dependent and induces inflammation of joints and skin lesions, which resemble the human disease (Khmaladze I et al., PMID: 25136095). At Idorsia, we are working in an in vivo immunology pharmacology laboratory and this model would be of high interest to evaluate the efficacy and mechanism of actions of in house-developed compounds. The candidate tasks would be to establish and characterize the previously described model, to validate the model with reference compounds, and in parallel to assess the efficacy of Idorsia compounds. If time permits, the candidate would also validate and optimize additional efficacy models in the lab to improve the in vivo characterization of Idorsia compounds.

Working location: Idorsia Pharmaceuticals Ltd, Hegenheimermattweg 91, 4123 Allschwil

Supervisors:
At University (Fakultätsvertreter): Prof. Stephan Krähenbühl and Prof. Matthias Liechti (matthias.liechti@usb.ch), Clinical Pharmacology, University Hospital Basel

At Idorsia: Master Thesis supervisor (Leiter der Arbeit im Labor): Dr. Marianne Martinic, PhD (marianne.martinic@idorsia.com), Director, Group Leader Immunology and Pharmacolgy; Direct supervisors: Anna Sassi and Jeremy Scherer (anna.sassi@idorsia.com, jeremy.scherer@idorsia.com)

Job Responsibilities:

  • Learn to design, plan, and perform in vivo experiments on rodents (timelines, compound administrations, clinical scoring, tissue collection)

  • Perform ex vivo analyses of collected rodent tissues such as flow cytometry, biomarker evaluation, enzyme activity measurements

  • Keep accurate record of literature search, experimental protocol, and results (laboratory notebook, PowerPoint presentations)

  • Present obtained data at lab meetings

  • Contribute to the general laboratory infrastructure, including coordination with colleagues about the daily workflow, organization, maintenance  

Candidate Requirements:

  • Bachelor degree in life sciences or equivalent, with knowledge in Pharmacology and ideally also Immunology

  • Practical research experience (knowledge of basic in vitro and sterile working techniques)

  • Wish to perform in vivo work with rodents; previous contact with rodents and qualified to perform animal experiments in Switzerland (LTK module 1 or equivalent) would be an asset

  • Enthusiastic, flexible, willingness to learn and self-motivated

  • Excellent communication and record-keeping skills, attention to detail, accuracy, commitment to work as part of a team

  • Fluent in both written and verbal communication in English; good German and French knowledge would be a plus

  • Basic computer skills (Excel, Word, PowerPoint, ideally also Prism)

anna.sassi@idorsia.com, jeremy.scherer@idorsia.comneinja