/ Research

Design, Synthesis, and Characterization of a Paclitaxel Formulation Activated by Extracellular MMP9

[Translate to English:] Graphicabstract

The concept of triggered drug release offers a possibility to overcome the toxic side effects of chemotherapeutics in cancer treatment by reducing systemic exposure to the active drug. In the present work, the concept foresees the use of the extracellular enzyme MMP9 as an enzymatic trigger for drug release in the proximity of tumor cells. More