Tiny fish under a giant camera
Metal-based nanoparticles are a promising tool in medicine – as a contrast agent, transporter of active substances, or to thermally kill tumor cells. Up to now, it has been hardly possible to study their distribution inside an organism. Researchers at the University of Basel have used a three-dimensional imaging method to take high-resolution captures inside zebrafish embryos.
To establish the effectiveness and safety of metal-based nanoparticles for medical applications, developers must investigate the particle distribution inside a living organism and detect their accumulation. Until now, the particles have had to be labeled with radioactive or fluorescent markers. Such marker molecules, however, can influence the distribution of the nanoparticles in the organism. In addition, a high dose of particles is needed and distorts the results. Read more