Publications
Happi, G.M. et al. (2025) “Vernonia sesquiterpene lactones: a review of their chemical and pharmacological aspects”, Phytochemistry Reviews [Preprint]. Available at: 10.1007/s11101-025-10101-0.
Teufel, R., Müller, M. (2025) “Giant Polyketide Synthases Biosynthesize a Marine Polyether Biotoxin”, Angewandte Chemie - International Edition, 64(4). Available at: 10.1002/anie.202419620.
Teufel, R., Müller, M. (2025) “Giant Polyketide Synthases Biosynthesize a Marine Polyether Biotoxin”, Angewandte Chemie, 137(4). Available at: 10.1002/ange.202419620.
Zdouc, M. et al. (2025) “MIBiG 4.0: advancing biosynthetic gene cluster curation through global collaboration”, Nucleic Acids Research, 53(D1), pp. D678-D690. Available at: 10.1093/nar/gkae1115.
Happi, G.M. et al. (2025) “Highly oxygenated antiplasmodial and non-hemolytic Δ7,9(11) stigmastane-type steroids from the twigs of Vernonia amygdalina Delile”, Phytochemistry, 229, p. 114286. Available at: 10.1016/j.phytochem.2024.114286.
Teufel, R. (2024) “Oxygen-transfer reactions by enzymatic flavin-N5 oxygen adducts—Oxidation is not a must”, Current Opinion in Chemical Biology, 80. Available at: 10.1016/j.cbpa.2024.102464.
Mouthé Happi, G., Teufel, R. (2024) “Steroids from the Meliaceae family and their biological activities”, Phytochemistry, 221. Available at: 10.1016/j.phytochem.2024.114039.
Moffat, A.D. et al. (2024) “Understanding the biosynthesis, metabolic regulation, and anti-phytopathogen activity of 3,7-dihydroxytropolone in Pseudomonas spp”. Cold Spring Harbor Laboratory. Available at: 10.1101/2024.04.03.587903.
Höing, L. et al. (2024) “Biosynthesis of the bacterial antibiotic 3,7-dihydroxytropolone through enzymatic salvaging of catabolic shunt products”, Chemical Science, 15(20), pp. 7749–7756. Available at: 10.1039/d4sc01715c.
Benka, M. et al. (2023) “Mass Spectrometric Analysis of Cucurbitacins and Dihydrocucurbitacins from the Tuber of Citrullus naudinianus”, Biomolecules, 13(8). Available at: 10.3390/biom13081168.
Zhang, L. et al. (2022) “Antibacterial Synnepyrroles from Human-Associated Nocardiopsis sp. Show Protonophore Activity and Disrupt the Bacterial Cytoplasmic Membrane”, ACS Chemical Biology, 17(10), pp. 2836–2848. Available at: 10.1021/acschembio.2c00460.
Toplak, M. et al. (2022) “An acetyltransferase controls the metabolic flux in rubromycin polyketide biosynthesis by direct modulation of redox tailoring enzymes”, Chemical Science, 13(24), pp. 7157–7164. Available at: 10.1039/d2sc01952c.
Matthews, A. et al. (2022) “Bacterial flavoprotein monooxygenase YxeK salvages toxic S-(2-succino)-adducts via oxygenolytic C–S bond cleavage”, FEBS Journal, 289(3), pp. 787–807. Available at: 10.1111/febs.16193.
Toplak, M., Teufel, R. (2022) “Three Rings to Rule Them All: How Versatile Flavoenzymes Orchestrate the Structural Diversification of Natural Products”, Biochemistry, 61(2), pp. 47–56. Available at: 10.1021/acs.biochem.1c00763. edoc
Zhang, L. et al. (2022) “Bacterial Dehydrogenases Facilitate Oxidative Inactivation and Bioremediation of Chloramphenicol”, ChemBioChem, 24(2), p. e202200632. Available at: 10.1002/cbic.202200632. edoc | Open Access
Toplak, M. et al. (2021) “Catalytic Control of Spiroketal Formation in Rubromycin Polyketide Biosynthesis”, Angewandte Chemie, 133(52), pp. 27166–27176. Available at: 10.1002/ange.202109384.
Frensch, B. et al. (2021) “Enzymatic spiroketal formation via oxidative rearrangement of pentangular polyketides”, Nature Communications, 12(1), p. 1431. Available at: 10.1038/s41467-021-21432-9.
Duan, Y. et al. (2021) “A Flavoprotein Dioxygenase Steers Bacterial Tropone Biosynthesis via Coenzyme A-Ester Oxygenolysis and Ring Epoxidation”, Journal of the American Chemical Society, 143(27), pp. 10413–10421. Available at: 10.1021/jacs.1c04996.
Toplak, M., Matthews, A., Teufel, R. (2021) “The devil is in the details: The chemical basis and mechanistic versatility of flavoprotein monooxygenases”, Archives of Biochemistry and Biophysics, 698, p. 108732. Available at: 10.1016/j.abb.2020.108732.
Duan, Y. et al. (2020) “Bacterial Tropone Natural Products and Derivatives: Overview of their Biosynthesis, Bioactivities, Ecological Role and Biotechnological Potential”, ChemBioChem, 21(17), pp. 2384–2407. Available at: 10.1002/cbic.201900786.
Tsypik, O. et al. (2020) “Oxidative Carbon Backbone Rearrangement in Rishirilide Biosynthesis”, Journal of the American Chemical Society, 142(13), pp. 5913–5917. Available at: 10.1021/jacs.9b12736.
Matthews, A. et al. (2020) “Aminoperoxide adducts expand the catalytic repertoire of flavin monooxygenases”, Nat. Chem. Biol, 16, pp. 556–563.
Spieker, M., Saleem-Batcha, R., Teufel, R. (2019) “Structural and Mechanistic Basis of an Oxepin-CoA Forming Isomerase in Bacterial Primary and Secondary Metabolism”, ACS Chemical Biology, 14(12), pp. 2876–2886. Available at: 10.1021/acschembio.9b00742.
Saleem-Batcha, R., Teufel, R. (2019) “Structural methods for probing the interaction of flavoenzymes with dioxygen and its surrogates”, Methods in Enzymology, 620, pp. 349–363. Available at: 10.1016/bs.mie.2019.03.016.
Saleem-Batcha, R., Teufel, R. (2018) “Insights into the enzymatic formation, chemical features, and biological role of the flavin-N5-oxide”, Current Opinion in Chemical Biology, 47, pp. 47–53. Available at: 10.1016/j.cbpa.2018.08.003.
Saleem-Batcha, R. et al. (2018) “Enzymatic control of dioxygen binding and functionalization of the flavin cofactor”, Proceedings of the National Academy of Sciences of the United States of America, 115(19), pp. 4909–4919. Available at: 10.1073/pnas.1801189115.
Teufel, R. (2018) “Unusual ‘Head-to-Torso’ Coupling of Terpene Precursors as a New Strategy for the Structural Diversification of Natural Products”, Methods in Enzymology, 604, pp. 425–439. Available at: 10.1016/bs.mie.2018.01.037.
Teufel, R. (2018) “Preparation and Characterization of the Favorskiiase Flavoprotein EncM and Its Distinctive Flavin-N5-Oxide Cofactor”, Methods in Enzymology, 604, pp. 523–540. Available at: 10.1016/bs.mie.2018.01.036.
Teufel, R. (2017) “Flavin-catalyzed redox tailoring reactions in natural product biosynthesis”, Archives of Biochemistry and Biophysics, 632, pp. 20–27. Available at: 10.1016/j.abb.2017.06.008.
Teufel, R., Agarwal, V., Moore, B.S. (2016) “Unusual flavoenzyme catalysis in marine bacteria”, Current Opinion in Chemical Biology, 31, pp. 31–39. Available at: 10.1016/j.cbpa.2016.01.001.
Teufel, R. et al. (2015) “Biochemical Establishment and Characterization of EncM’s Flavin-N5-oxide Cofactor”, Journal of the American Chemical Society, 137(25), pp. 8078–8085. Available at: 10.1021/jacs.5b03983.
Bonet, B. et al. (2015) “Direct capture and heterologous expression of salinispora natural product genes for the biosynthesis of enterocin”, Journal of Natural Products, 78(3), pp. 539–542. Available at: 10.1021/np500664q.
Diethelm, S. et al. (2014) “A multitasking vanadium-dependent chloroperoxidase as an inspiration for the chemical synthesis of the merochlorins”, Angewandte Chemie - International Edition, 53(41), pp. 11023–11026. Available at: 10.1002/anie.201405696.
Teufel, R. et al. (2014) “One-pot enzymatic synthesis of merochlorin A and B”, Angewandte Chemie - International Edition, 53(41), pp. 11019–11022. Available at: 10.1002/anie.201405694.
Teufel, R. et al. (2013) “Flavin-mediated dual oxidation controls an enzymatic Favorskii-type rearrangement”, Nature, 503(7477), pp. 552–556. Available at: 10.1038/nature12643.
Teufel, R., Friedrich, T., Fuchs, G. (2012) “An oxygenase that forms and deoxygenates toxic epoxide”, Nature, 483(7389), pp. 359–362. Available at: 10.1038/nature10862.
Teufel, R. et al. (2011) “Studies on the mechanism of ring hydrolysis in phenylacetate degradation: A metabolic branching point”, Journal of Biological Chemistry, 286(13), pp. 11021–11034. Available at: 10.1074/jbc.M110.196667.
Teufel, R. et al. (2010) “Bacterial phenylalanine and phenylacetate catabolic pathway revealed”, Proceedings of the National Academy of Sciences of the United States of America, 107(32), pp. 14390–14395. Available at: 10.1073/pnas.1005399107.
Teufel, R. et al. (2009) “3-Hydroxypropionyl-coenzyme A dehydratase and acryloyl-coenzyme A reductase, enzymes of the autotrophic 3-hydroxypropionate/4-hydroxybutyrate cycle in the Sulfolobales”, Journal of Bacteriology, 191(14), pp. 4572–4581. Available at: 10.1128/JB.00068-09.