2020

Mancuso, R. V., Casper, J., Schmidt, A. G., Krähenbühl, S. und Weitz-Schmidt, G. (2020) «Anti-αLβ2 antibodies reveal novel endocytotic cross-modulatory functionality», British Journal of Pharmacology. Wiley, 177(12), S. 2696-2711. doi: 10.1111/bph.14996.   edoc
Schneider, R., Reinau, D., Schur, N., Blozik, E., Früh, M., Signorell, A., Heininger, U., Schwenkglenks, M. und Meier, C. R. (2020) «Coverage rates and timeliness of nationally recommended vaccinations in Swiss preschool children: A descriptive analysis using claims data», Vaccine. Elsevier, 38(6), S. 1551-1558. doi: 10.1016/j.vaccine.2019.11.057.   edoc
Pironi, L., Boeykens, K., Bozzetti, F., Joly, F., Klek, S., Lal, S., Lichota, M., Mühlebach, S., Van Gossum, A., Wanten, G., Wheatley, C. und Bischoff, S. C. (2020) «ESPEN guideline on home parenteral nutrition», Clinical Nutrition. Elsevier, 39(6), S. 1645-1666. doi: 10.1016/j.clnu.2020.03.005.   edoc | Open Access
Don, C. G. und Smieško, M. (2020) «In Silico Pharmacogenetics CYP2D6 Study Focused on the Pharmacovigilance of Herbal Antidepressants», Frontiers in Pharmacology. Frontiers Media, 11, S. 683. doi: 10.3389/fphar.2020.00683.   edoc | Open Access
Liu, J., Craciun, I., Belluati, A., Wu, D., Sieber, S., Einfalt, T., Witzigmann, D., Chami, M., Huwyler, J. und Palivan, C. G. (2020) «DNA-directed arrangement of soft synthetic compartments and their behavior in vitro and in vivo», Nanoscale. Royal Society of Chemistry, 12(17), S. 9786-9799. doi: 10.1039/d0nr00361a.   edoc | Open Access
Lizák, B., Birk, J., Zana, M., Kosztyi, G., Kratschmar, D. V., Odermatt, A., Zimmermann, R., Geiszt, M., Appenzeller-Herzog, C. und Bánhegyi, G. (2020) «Ca2+ mobilization-dependent reduction of the endoplasmic reticulum lumen is due to influx of cytosolic glutathione», BMC Biology. BioMed Central, 18(1), S. 19. doi: 10.1186/s12915-020-0749-y.   edoc | Open Access
Einfalt, T., Garni, M., Witzigmann, D., Sieber, S., Baltisberger, N., Huwyler, J., Meier, W. und Palivan, C. (2020) «Bioinspired Molecular Factories with Architecture and In Vivo Functionalities as Cell Mimics», Advanced Science. Wiley, 7(4), S. 1901923. doi: 10.1002/advs.201901923.   edoc | Open Access
Yokoyama, R., Kimura, G., Huwyler, J., Hosoya, K.- ichi und Puchkov, M. (2020) «Impact of Insoluble Separation Layer Mechanical Properties on Disintegration and Dissolution Kinetics of Multilayer Tablets», pharmaceutics, 12(495), S. 12060495. doi: 10.3390/pharmaceutics12060495.   
Bouitbir, J., Panajatovic, M. V., Frechard, T., Roos, N. J. und Krähenbühl, S. (2020) «Imatinib and Dasatinib Provoke Mitochondrial Dysfunction Leading to Oxidative Stress in C2C12 Myotubes and Human RD Cells», Frontiers in pharmacology, 11, S. 1106. doi: 10.3389/fphar.2020.01106.   
Randi, E. B., Vervaet, B., Tsachaki, M., Porto, E., Vermeylen, S., Lindenmeyer, M. T., Thuy, L. T. T., Cohen, C. D., Devuyst, O., Kistler, A. D., Szabo, C., Kawada, N., Hankeln, T., Odermatt, A., Dewilde, S., Wenger, R. H. und Hoogewijs, D. (2020) «The Antioxidative Role of Cytoglobin in Podocytes: Implications for a Role in Chronic Kidney Disease», Antioxidants & redox signaling, 32(16), S. 1155-1171. doi: 10.1089/ars.2019.7868.   
Fischer, A. und Smieško, M. (2020) «Allosteric Binding Sites On Nuclear Receptors: Focus On Drug Efficacy and Selectivity», International journal of molecular sciences, 21(2), S. 534. doi: 10.3390/ijms21020534.   
Tsachaki, M., Strauss, P., Dunkel, A., Navrátilová, H., Mladenovic, N. und Odermatt, A. (2020) «Impact of 17β-HSD12, the 3-ketoacyl-CoA reductase of long-chain fatty acid synthesis, on breast cancer cell proliferation and migration», Cellular and molecular life sciences : CMLS, 77(6), S. 1153-1175. doi: 10.1007/s00018-019-03227-w.   
Burkard, T., Rauch, M., Spoendlin, J., Prieto-Alhambra, D., Jick, S. S. und Meier, C. R. (2020) «Risk of hand osteoarthritis in new users of hormone replacement therapy: A nested case-control analysis», Maturitas, 132, S. 17-23. doi: 10.1016/j.maturitas.2019.11.006.   
Dreckmann, T., Ludwig, I.-S., Boeuf, J., Lümkemann, J. und Huwyler, J. (2020) «Low Volume Aseptic Filling: Impact of Pump Systems on Shear Stress», European Journal of Pharmaceutics and Biopharmaceutics, 147, S. 10-18. doi: 10.1016/j.ejpb.2019.12.006.   
Schuster, J., Koulov, A., Mahler, H.-C., Joerg, S., Huwyler, J., Schleicher, K., Detampel, P. und Mathaes, R. (2020) «Particle Analysis of Biotherapeutics in Human Serum Using Machine Learning», Journal of Pharmaceutical Sciences, 109, S. 1827-1832. doi: 10.1016/j.xphs.2020.02.015.   
Lederer, A.-K., Maul-Pavicic, A., Hannibal, L., Hettich, M., Steinborn, C., Gründemann, C., Zimmermann-Klemd, A. M., Müller, A., Sehnert, B., Salzer, U., Klein, R., Voll, R. E., Samstag, Y. und Huber, R. (2020) «Vegan diet reduces neutrophils, monocytes and platelets related to branched-chain amino acids - A randomized, controlled trial», Clinical nutrition (Edinburgh, Scotland), S. Epub ahead of print. doi: 10.1016/j.clnu.2020.02.011.   
Schuster, J., Mahler, H.-C., Koulov, A., Joerg, S., Racher, A., Huwyler, J., Detampel, P. und Mathaes, R. (2020) «Tracking the physical stability of fluorescent-labeled mAbs under physiologic invitro conditions in human serum and PBS», European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 152, S. 193-201. doi: 10.1016/j.ejpb.2020.04.014.   
Panajatovic, M., Singh, F., Duthaler, U., Krähenbühl, S. und Bouitbir, J. (2020) «Role of PGC-1-alpha-associated Mitochondrial Biogenesis in Statin-induced Myotoxicity», European cardiology, 15, S. e35. doi: 10.15420/ecr.2020.15.1.PO12.   
Suenderhauf, C., Berger, B., Puchkov, M., Schmid, Y., Müller, S., Huwyler, J., Haschke, M., Krähenbühl, S. und Duthaler, U. (2020) «Pharmacokinetics and phenotyping properties of the ‹Basel› phenotyping cocktail combination capsule in healthy male adults», British journal of clinical pharmacology, S. 1-10. doi: 10.1111/bcp.14157.   
Roth, N., Sandström, J. und Wilks, M. F. (2020) «A case study applying pathway-oriented thinking to problem formulation for planning a systematic review», Environment international, 140, S. 105768. doi: 10.1016/j.envint.2020.105768.   
Cörek, E., Rodgers, G., Siegrist, S., Einfalt, T., Detampel, P., Schlepütz, C. M., Sieber, S., Fluder, P., Schulz, G., Unterweger, H., Alexiou, C., Müller, B., Puchkov, M. und Huwyler, J. (2020) «Shedding Light on Metal-Based Nanoparticles in Zebrafish by Computed Tomography with Micrometer Resolution», Small, 2000746, S. 1-10. doi: 10.1002/smll.202000746.   
Sanvee, G. M., Panajatovic, M., Bouitbir, D. J. und Krähenbühl, D. (2020) «Statins and Insulin Resistance», European cardiology, 15, S. e44. doi: 10.15420/ecr.2020.15.1.PO21.   
Beck, K. R., Thompson, G. R. und Odermatt, A. (2020) «Drug-induced endocrine blood pressure elevation», Pharmacological research, 154, S. 104311. doi: 10.1016/j.phrs.2019.104311.   
Nguyen, M.-V. H., Davis, M. R., Wittenberg, R., Mchardy, I., Baddley, J. W., Young, B. Y., Odermatt, A. und Thompson, G. R. (2020) «Posaconazole Serum Drug Levels Associated With Pseudohyperaldosteronism», Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 70(12), S. 2593-2598. doi: 10.1093/cid/ciz741.   
Sedighi, M., Rahimi, F., Shahbazi, M.-A., Rezayan, A. H., Kettiger, H., Einfalt, T., Huwyler, J. und Witzigmann, D. (2020) «Controlled Tyrosine Kinase Inhibitor Delivery to Liver Cancer Cells by Gate-Capped Mesoporous Silica Nanoparticles», ACS Applied Bio Materials, 3, S. 239-251. doi: 10.1021/acsabm.9b00772.   
Inderbinen, S. G., Engeli, R. T., Rohrer, S. R., Di Renzo, E., Aengenheister, L., Buerki-Thurnherr, T. und Odermatt, A. (2020) «Tributyltin and triphenyltin induce 11β-hydroxysteroid dehydrogenase 2 expression and activity through activation of retinoid X receptor α», Toxicology letters, 322, S. 39-49. doi: 10.1016/j.toxlet.2020.01.001.   
Chilczuk, T., Steinborn, C., Breinlinger, S., Zimmermann-Klemd, A. M., Huber, R., Enke, H., Enke, D., Niedermeyer, T. H. J. und Gründemann, C. (2020) «Hapalindoles from the Cyanobacterium Hapalosiphon sp. Inhibit T Cell Proliferation», Planta medica, 86(2), S. 96-103. doi: 10.1055/a-1045-5178.   
Wilks, M. F. (2020) «Bringing Chemistry to Medicine - The Contribution of Paracelsus to Modern Toxicology», Chimia, 74(6), S. 507-508. doi: 10.2533/chimia.2020.507.   
Gómez, C., Stücheli, S., Kratschmar, D. V., Bouitbir, J. und Odermatt, A. (2020) «Development and Validation of a Highly Sensitive LC-MS/MS Method for the Analysis of Bile Acids in Serum, Plasma, and Liver Tissue Samples», Metabolites, 10(7), S. 282. doi: 10.3390/metabo10070282.   
Häuser, C., Goldbach, P., Huwyler, J., Friess, W. und Allmendinger, A. (2020) «Excipients for Room Temperature Stable Freeze-Dried Monoclonal Antibody Formulations», Journal of Pharmaceutical Sciences, 109, S. 807-817. doi: 10.1016/j.xphs.2019.10.016.   
Panajatovic, M. V., Singh, F., Roos, N. J., Duthaler, U., Handschin, C., Krähenbühl, S. und Bouitbir, J. (2020) «PGC-1α plays a pivotal role in simvastatin-induced exercise impairment in mice», Acta physiologica (Oxford, England), 228(4), S. e13402. doi: 10.1111/apha.13402.   
Brecht Brüngger, K., Schäfer, A. M. und Meyer zu Schwabedissen, H. E. (2020) «Uptake Transporters of the SLC21, SLC22A, and SLC15A Families in Anticancer Therapy - Modulators of Cellular Entry or Pharmacokinetics?», Cancers. mdpi, 12(8), S. 2263-2294. doi: 10.3390/cancers12082263.   
Schittny, A., Huwyler, J. und Puchkov, M. (2020) «Mechanisms of increased bioavailability through amorphous solid dispersions: a review», Drug delivery, 27(1), S. 110-127. doi: 10.1080/10717544.2019.1704940.   
Wagner-Hattler, L., Québatte, G., Keiser, J., Schoelkopf, J., Schlepütz, C. M., Huwyler, J. und Puchkov, M. (2020) «Study of drug particle distributions within mini-tables using synchrotron X-ray microtomography and superpixel image clustering», International Journal of Pharmaceutics, 573, S. 118827. doi: 10.1016/j.ijpharm.2019.118827.   
Kroezen, B., Conti, G., Girardi, B., Cramer, J., Jiang, X., Rabbani, S., Müller, J., Kokot, M., Luisoni, E., Ricklin, D., Schwardt, O. und Ernst, B. (2020) «A Potent Mimetic of the Siglec-8 Ligand 6’-Sulfo-Sialyl Lewisx», ChemMedChem, S. Online ahead of print. doi: 10.1002/cmdc.202000417.   
Ehrsam, D., Sieber, S., Oufir, M., Porta, F., Hamburger, M., Huwyler, J. und Meyer zu Schwabedissen, H. E. (2020) «Design, Synthesis, and Characterization of a Paclitaxel Formulation Activated by Extracellular MMP9», Bioconjugate Chemistry, 31, S. 781-793. doi: 10.1021/acs.bioconjchem.9b00865.   
Patt, M., Beck, K. R., Di Marco, T., Jäger, M.-C., González-Ruiz, V., Boccard, J., Rudaz, S., Hartmann, R. W., Salah, M., van Koppen, C. J., Grill, M. und Odermatt, A. (2020) «Profiling of anabolic androgenic steroids and selective androgen receptor modulators for interference with adrenal steroidogenesis», Biochemical pharmacology, 172, S. 113781. doi: 10.1016/j.bcp.2019.113781.   
Zhou, X., Bouitbir, J., Liechti, M. E., Krähenbühl, S. und Mancuso, R. V. (2020) «Para; -Halogenation of Amphetamine and Methcathinone Increases the Mitochondrial Toxicity in Undifferentiated and Differentiated SH-SY5Y Cells», International journal of molecular sciences, 21(8), S. 2841. doi: 10.3390/ijms21082841.   
Schuster, J., Koulov, A., Mahler, H.-C., Detampel, P., Huwyler, J., Singh, S. und Mathaes, R. (2020) «In Vivo Stability of Therapeutic Proteins», Pharmaceutical research, 37(2), S. 23. doi: 10.1007/s11095-019-2689-1.   
Roos, N. J., Aliu, D., Bouitbir, J. und Krähenbühl, S. (2020) «Lapatinib Activates the Kelch-Like ECH-Associated Protein 1-Nuclear Factor Erythroid 2-Related Factor 2 Pathway in HepG2 Cells», Frontiers in pharmacology, 11, S. 944. doi: 10.3389/fphar.2020.00944.   

2019

Sauer, M. M., Jakob, R. P., Luber, T., Canonica, F., Navarra, G., Ernst, B., Unverzagt, C., Maier, T. und Glockshuber, R. (2019) «Binding of the bacterial adhesin FimH to its natural, multivalent high-mannose type glycan targets», Journal of the American Chemical Society. American Chemical Society, 141(2), S. 936-944. doi: 10.1021/jacs.8b10736.   edoc
Bleher, S., Buck, J., Muhl, C., Sieber, S., Barnert, S., Witzigmann, D., Huwyler, J., Braz, M. und Süss, R. (2019) «Poly(Sarcosine) Surface Modification Imparts Stealth‐Like Properties to Liposomes», Small. Wiley, 15(50), S. 1904716. doi: 10.1002/smll.201904716.   edoc
Zhou, X., Luethi, D., Sanvee, G. M., Bouitbir, J., Liechti, M. E. und Krähenbühl, S. (2019) «Molecular Toxicological Mechanisms of Synthetic Cathinones on C2C12 Myoblasts», International journal of molecular sciences. Multidisciplinary Digital Publishing Institute, 20(7), S. 1561. doi: 10.3390/ijms20071561.   edoc
Bühler, T., Medinger, M., Bouitbir, J., Krähenbühl, S. und Leuppi-Taegtmeyer, A. (2019) «Hepatotoxicity Due to Azole Antimycotic Agents in a HLA B*35:02-Positive Patient», Frontiers in pharmacology. Frontiers Media, 10, S. 645. doi: 10.3389/fphar.2019.00645.   edoc
Bouitbir, J., Alshaikhali, A., Panajatovic, M. V., Abegg, V. F., Paech, F. und Krähenbühl, S. (2019) «Mitochondrial oxidative stress plays a critical role in the cardiotoxicity of sunitinib: Running title: Sunitinib and oxidative stress in hearts », Toxicology. Elsevier, 426, S. 152281. doi: 10.1016/j.tox.2019.152281.   edoc
Sedighi, M., Sieber, S., Rahimi, F., Shahbazi, M.-A., Rezayan, A. H., Huwyler, J. und Witzigmann, D. (2019) «Rapid optimization of liposome characteristics using a combined microfluidics and design-of-experiment approach», Drug delivery and translational research. Springer, 9(1), S. 404-413. doi: 10.1007/s13346-018-0587-4.   edoc
van Griensven, M., Ricklin, D., Denk, S., Halbgebauer, R., Braun, C. K., Schultze, A., Hönes, F., Koutsogiannaki, S., Primikyri, A., Reis, E., Messerer, D., Hafner, S., Radermacher, P., Biglarnia, A.-R., Resuello, R. R. G., Tuplano, J. V., Mayer, B., Nilsson, K., Nilsson, B., Lambris, J. D. und Huber-Lang, M. (2019) «Protective Effects of the Complement Inhibitor Compstatin CP40 in Hemorrhagic Shock», Shock. Lippincott, Williams & Wilkins, 51(1), S. 78-87. doi: 10.1097/SHK.0000000000001127.   edoc
Mastellos, D. C., Blom, A. M., Connolly, E. S., Daha, M. R., Geisbrecht, B. V., Ghebrehiwet, B., Gros, P., Hajishengallis, G., Holers, V. M., Huber-Lang, M., Kinoshita, T., Mollnes, T. E., Montgomery, R. A., Morgan, B. P., Nilsson, B., Pio, R., Ricklin, D., Risitano, A. M., Taylor, R. P., Mantovani, A., Ioannidis, J. P. A. und Lambris, J. D. (2019) «’Stealth’ corporate innovation: an emerging threat for therapeutic drug development», Nature immunology, 20(11), S. 1409-1413. doi: 10.1038/s41590-019-0503-1.   edoc
Baas, I., Delvasto-Nuñez, L., Ligthart, P., Brouwer, C., Folman, C., Reis, E. S., Ricklin, D., Lambris, J. D., Wouters, D., de Haas, M., Jongerius, I. und Zeerleder, S. S. (2019) «Complement C3 inhibition by compstatin Cp40 prevents intra- and extravascular hemolysis of red blood cells», Haematologica, 105(2), S. inress. doi: 10.3324/haematol.2019.216028.   edoc
Mastellos, D. C., Ricklin, D. und Lambris, J. D. (2019) «Clinical promise of next-generation complement therapeutics», Nature reviews. Drug discovery, 18(9), S. 707-729. doi: 10.1038/s41573-019-0031-6.   edoc
Lombardi, E., Matte, A., Risitano, A. M., Ricklin, D., Lambris, J. D., De Zanet, D., Jokiranta, S. T., Martinelli, N., Scambi, C., Salvagno, G., Bisoffi, Z., Colato, C., Siciliano, A., Bortolami, O., Mazzuccato, M., Zorzi, F., De Marco, L. und De Franceschi, L. (2019) «Factor H interferes with the adhesion of sickle red cells to vascular endothelium: a novel disease-modulating molecule», Haematologica, 104(5), S. 919-928. doi: 10.3324/haematol.2018.198622.   edoc
Häuser, C., Goldbach, P., Huwyler, J., Fiess, W. und Allmendinger, A. (2019) «Be Aggressive! Amorphous Excipients Enabling Single-Step Freeze-Drying of Monoclonal Antibody Formulations», Pharmaceutics. MDPI, 11(11), S. 616. doi: 10.3390/pharmaceutics11110616.   edoc
Sanvee, G. M., Bouitbir, J. und Krähenbühl, S. (2019) «Insulin prevents and reverts simvastatin-induced toxicity in C2C12 skeletal muscle cells», Scientific reports. Nature Publishing Group, 9(1), S. 7409. doi: 10.1038/s41598-019-43938-5.   edoc
Sanvee, G. M., Panajatovic, M. V., Bouitbir, J. und Krähenbühl, S. (2019) «Mechanisms of insulin resistance by simvastatin in C2C12 myotubes and in mouse skeletal muscle», Biochemical pharmacology. Elsevier, 164, S. 23-33. doi: 10.1016/j.bcp.2019.02.025.   edoc
Singh, F., Zoll, J., Duthaler, U., Charles, A.-L., Panajatovic, M. V., Laverny, G., McWilliams, T. G., Metzger, D., Geny, B., Krähenbühl, S. und Bouitbir, J. (2019) «PGC-1β modulates statin-associated myotoxicity in mice», Archives of Toxicology. Springer, 93(2), S. 487-504. doi: 10.1007/s00204-018-2369-7.   edoc
Bouitbir, J., Sanvee, G. M., Panajatovic, M. V., Singh, F. und Krähenbühl, S. (2019) «Mechanisms of statin-associated skeletal muscle-associated symptoms», Pharmacological research. Elsevier, (154), S. 104201. doi: 10.1016/j.phrs.2019.03.010.   edoc
Reber, E., Messerli, M., Stanga, Z. und Mühlebach, S. (2019) «Pharmaceutical Aspects of Artificial Nutrition», Journal of clinical medicine, 8(11), S. jcm8112017. doi: 10.3390/jcm8112017.   edoc
Dias, C., Matos, A. M., Blasquez-Sanchez, M. T., Calado, P., Martins, A., Daetwyler, P., Ernst, B., Macedo, M. P., Colabufo, N. und Rauter, A. (2019) «2-Deoxyglycosylation towards more effective and bioavailable neuroprotective molecules inspired by nature», Pure and applied chemistry. de Gruyter, 91(7), S. 1209-1221. doi: 10.1515/pac-2019-0303.   edoc
Santos, S., Haslinger, C., Mennet, M., von Mandach, U., Hamburger, M. und Simões-Wüst, A. P. (2019) «Bryophyllum pinnatum enhances the inhibitory effect of atosiban and nifedipine on human myometrial contractility: an in vitro study», BMC Complem. Altern. Med, 19(1), S. 292. doi: 10.1186/s12906-019-2711-5.   edoc | Open Access
Flühmann, B., Ntai, I., Borchard, G., Simoens, S. und Mühlebach, S. (2019) «Nanomedicines: The magic bullets reaching their target?», European journal of pharmaceutical sciences. Elsevier, 128, S. 73-80. doi: 10.1016/j.ejps.2018.11.019.   edoc
Mühlebach , S. F. (2019) «Diets and Diet Therapy: Parenteral Nutrition», Encyclopedia of Food Security and Sustainability (FOSS). Elsevier, 2, S. 131-142. doi: 10.1016/B978-0-08-100596-5.21937-9.   edoc
Malagnino, V., Hussner, J., Issa, A., Midzic, A. und Meyer zu Schwabedissen, H. E. (2019) «OATP1B3-1B7 a novel Organic Anion Transporting Polypeptide is modulated by FXR ligands and transports bile acids», American journal of physiology. Gastrointestinal and liver physiology, 316(6), S. G751-G762. doi: 10.1152/ajpgi.00330.2018.   edoc
Cramer, J., Sager, C. P. und Ernst, B. (2019) «Hydroxyl Groups in Synthetic and Natural-Product-Derived Therapeutics: A Perspective on a Common Functional Group», Journal of medicinal chemistry, 62(20), S. 8915-8930. doi: 10.1021/acs.jmedchem.9b00179.   edoc
Mertenat, D., Dal Cero, M., Vogl, C. R., Ivemeyer, S., Meier, B., Maeschli, A., Hamburger, M. und Walkenhorst, M. (2019) «Ethnoveterinary knowledge of farmers in bilingual regions of Switzerland - is there potential to extend veterinary options to reduce antimicrobial use?», Journal of ethnopharmacology. Elsevier Science, 246, S. 112184. doi: 10.1016/j.jep.2019.112184.   edoc
Reinhardt, J. K., Klemd, A. M., Danton, O., De Mieri, M., Smiesko, M., Huber, R., Bürgisser, T., Gründemann, C. und Hamburger, M. (2019) «Sesquiterpene lactones from Artemisia argyi - absolute configuration and immunosuppressive activity», Journal of Natural Products. American Chemical Society, 82(6), S. 1424-1433. doi: 10.1021/acs.jnatprod.8b00791.   edoc
Fischer, A. und Smieško, M. (2019) «Spontaneous Ligand Access Events to Membrane-Bound Cytochrome P450 2D6 Sampled at Atomic Resolution», Scientific reports, 9(1), S. 16411. doi: 10.1038/s41598-019-52681-w.   edoc
Fischer, A. und Smieško, M. (2019) «Ligand Pathways in Nuclear Receptors», Journal of chemical information and modeling, 59(7), S. 3100-3109. doi: 10.1021/acs.jcim.9b00360.   edoc
Beilmann, M., Boonen, H., Czich, A., Dear, G., Hewitt, P., Mow, T., Newham, P., Oinonen, T., Pognan, F., Roth, A., Valentin, J.-P., Van Goethem, F., Weaver, R. J., Birk, B., Boyer, S., Caloni, F., Chen, A. E., Corvi, R., Cronin, M. T. D., Daneshian, M., Ewart, L. C., Fitzgerald, R. E., Hamilton, G. A., Hartung, T., Kangas, J. D., Kramer, N. I., Leist, M., Marx, U., Polak, S., Rovida, C., Testai, E., Van der Water, B., Vulto, P. und Steger-Hartmann, T. (2019) «Optimizing drug discovery by Investigative Toxicology: Current and future trends», ALTEX, 36(2), S. 289-313. doi: 10.14573/altex.1808181.   edoc
de Matos, A. M., Martins, A., Man, T., Evans, D., Walter, M., Oliveira, M. C., López, Óscar, Fernandez-Bolaños, J. G., Dätwyler, P., Ernst, B., Macedo, M. P., Contino, M., Colabufo, N. A. und Rauter, A. P. (2019) «Design and Synthesis of CNS-targeted Flavones and Analogues with Neuroprotective Potential Against H; 2; O; 2; - and Aβ; 1-42; -Induced Toxicity in SH-SY5Y Human Neuroblastoma Cells», Pharmaceuticals (Basel, Switzerland), 12(2), S. 98. doi: 10.3390/ph12020098.   edoc
Faleschini, M. T., Maier, A., Fankhauser, S., Thasis, K., Hebeisen, S., Butterweck, V. und Hamburger, M. (2019) «Discovery of GABAA receptor modulators of natural origin - Validation of a FLIPR assay for screening and HPLC-based activity profiling», Planta Medica. Georg Thieme Verlag, 85(18), S. 1586. doi: 10.1055/s-0039-3400027.   edoc
Kahnamoei, M. B., Tabefam, M., Ebrahimi, S. N., Danton, O., Hamburger, M. und Farimani, M. M. (2019) «Chemical constituents from the ethyl acetate extract of Salvia hydrangea DC. ex Benth», Natural Product Communications. Natural Product, 14(6), S. 1934578X1984885. doi: 10.1177/1934578X19848852 .   edoc
Roel-Touris, J., Don, C. G., Vargas Honorato, R., Rodrigues, J. P. G. L. M. und Bonvin, A. M. J. J. (2019) «Less is more: Coarse-grained integrative modeling of large biomolecular assemblies with HADDOCK», Journal of chemical theory and computation. American Chemical Society, 15(11), S. 6358-6367. doi: 10.1021/acs.jctc.9b00310.   edoc
Ehrsam, D., Porta, F., Hussner, J., Seibert, I. und Meyer Zu Schwabedissen, H. E. (2019) «PDMS-PMOXA-Nanoparticles Featuring a Cathepsin B-Triggered Release Mechanism», Materials. MDPI, 12(17), S. 2836. doi: 10.3390/ma12172836.   edoc
Hevey, R. (2019) «Bioisosteres of Carbohydrate Functional Groups in Glycomimetic Design», Biomimetics. MDPI AG, 4(3), S. 53. doi: 10.3390/biomimetics4030053.   edoc
Ehrsam, D., Porta, F., Mori, M., Meyer zu Schwabedissen, H. E., Dalla Via, L., Garcia-Argaez, A. N., Basile, L., Meneghetti, F., Villa, S. und Gelain, A. (2019) «Unravelling the Antiproliferative Activity of 1,2,5-oxadiazole Derivatives», Anticancer Research. Stanford University Highwire Press, 39(7), S. 3453-3461. doi: 10.21873/anticanres.13491.   edoc
Malagnino, V., Duthaler, U., Seibert, I., Krähenbühl, S. und Meyer Zu Schwabedissen, H. E. (2019) «OATP1B3-1B7 (LST-3TM12) Is a Drug Transporter That Affects Endoplasmic Reticulum Access and the Metabolism of Ezetimibe», Molecular Pharmacology. American Society for Pharmacology and Experimental Therapeutics, 96(2), S. 128-137. doi: 10.1124/mol.118.114934.   edoc
Ferreira, C., Meyer, R. und Meyer Zu Schwabedissen, H. E. (2019) «The nuclear receptors PXR and LXR are regulators of the scaffold protein PDZK1», Biochimica et biophysica acta. Gene regulatory mechanisms. Elsevier, 1862(4), S. 447-456. doi: 10.1016/j.bbagrm.2019.02.007.   edoc
Schäfer, A. M., Potterat, O., Seibert, I., Fertig, O. und Meyer Zu Schwabedissen, H. E. (2019) «Hyperforin-Induced Activation of the Pregnane X Receptor Is Influenced by the Organic Anion-Transporting Polypeptide 2B1», Molecular Pharmacology. American Society for Pharmacology and Experimental Therapeutics, 95(3), S. 313-323. doi: 10.1124/mol.118.114066.   edoc
Kiene, K., Hayasi, N., Burhenne, J., Uchitomi, R., Sünderhauf, C., Schmid, Y., Haschke, M., Haefeli, W. E., Krähenbühl, S., Mikus, G., Inada, H. und Huwyler, J. (2019) «Microdosed midazolam for the determination of cytochrome P450 3A activity: Development and clinical evaluation of a buccal film», European Journal of Pharmaceutical Sciences. Elsevier, 135, S. 77-82. doi: 10.1016/j.ejps.2019.05.010.   edoc
Sandström, J., Kratschmar, D. V., Broyer, A., Poirot, O., Marbet, P., Chantong, B., Zufferey, F., Dos Santos, T., Boccard, J., Chrast, R., Odermatt, A. und Monnet-Tschudi, F. (2019) «In vitro models to study insulin and glucocorticoids modulation of trimethyltin (TMT)-induced neuroinflammation and neurodegeneration, and in vivo validation in db/db mice », Archives of toxicology, 93, S. 1649-1664. doi: 10.1007/s00204-019-02455-0.   edoc

2018

Rabbani, S., Fiege, B., Eris, D., Silbermann, M., Jakob, R. P., Navarra, G., Maier, T. und Ernst, B. (2018) «Conformational Switch of the Bacterial Adhesin FimH in the Absence of the Regulatory Domain: Engineering a Minimalistic Allosteric System», Journal of Biological Chemistry. American Society for Biochemistry and Molecular Biology, 293(5), S. 1835-1849. doi: 10.1074/jbc.M117.802942.   edoc
Ditter, D., Nieto, A., Mahler, H.-C., Roehl, H., Wahl, M., Huwyler, J. und Allmendinger, A. (2018) «Evaluation of Glass Delamination Risk in Pharmaceutical 10 mL/10R Vials», Journal of Pharmaceutical Sciences, 107(2), S. 624-637. doi: 10.1016/j.xphs.2017.09.016.   edoc
Thuerig, B., Ramseyer, J., Hamburger, M., Ludwig, M., Oberhänsli, T., Potterat, O., Schärer, H.-J. und Tamm, L. (2018) «Efficacy of a Magnolia officinalis bark extract against grapevine downy mildew and apple scab under controlled and field conditions», Crop Protection. Elsevier, 114, S. 97-105. doi: 10.1016/j.cropro.2018.08.011.   edoc
Yokoyama, R., Kimura, G., Schlepütz, C. M., Huwyler, J. und Puchkov, M. (2018) «Modeling of Disintegration and Dissolution Behavior of Mefenamic Acid Formulation Using Numeric Solution of Noyes-Whitney Equation with Cellular Automata on Microtomographic and Algorithmically Generated Surfaces», Pharmaceutics. MDPI, 10(4), S. 259. doi: 10.3390/pharmaceutics10040259.   edoc | Open Access
Bahadori, M. B., Eskandani, M., De Mieri, M., Hamburger, M. und Nazemiyeh, H. (2018) «Anti-proliferative activity-guided isolation of clerodermic acid from Salvia nemorosa L.: Geno/cytotoxicity and hypoxia-mediated mechanism of action», Food and chemical toxicology. Elsevier, 120, S. 155-163. doi: 10.1016/j.fct.2018.06.060.   edoc
Farimani, M. M., Khodaei, B., Moradi, H., Aliabadi, A., Ebrahimi, S. N., De Mieri, M., Kaiser, M. und Hamburger, M. (2018) «Phytochemical study of Salvia leeriifolia roots: rearranged abietane diterpenoids with antiprotozoal activity», Journal of Natural Products. American Chemical Society, 81(6), S. 1384-1390. doi: 10.1021/acs.jnatprod.7b01019.   edoc
Tabefam, M., Moridi Farimani, M., Danton, O., Ramseyer, J., Kaiser, M., Ebrahimi, S. N., Salehi, P., Batooli, H., Potterat, O. und Hamburger, M. (2018) «Antiprotozoal diterpenes from Perovskia abrotanoides», Planta Medica. Georg Thieme , 84(12-13), S. 913-919. doi: 10.1055/a-0608-4946.   edoc
Sedighi, M., Rahimi, F., Rezayan, A. H., Shahbazi, M.-A., Witzigmann, D. und Huwyler, J. (2018) «Combined cerium oxide nanocapping and layer-by-layer coating of porous silicon containers for controlled drug release», Journal of Materials Science. Springer, 53(21), S. 14975-14988. doi: 10.1007/s10853-018-2731-4.   edoc
Campbell, F., Bos, F. L., Sieber, S., Arias-Alpizar, G., Koch, B. E., Huwyler, J., Kros, A. und Bussmann, J. (2018) «Directing Nanoparticle Biodistribution through Evasion and Exploitation of Stab2-Dependent Nanoparticle Uptake», ACS Nano. American Chemical Society, 12(3), S. 2138-2150. doi: 10.1021/acsnano.7b06995.   edoc
Mingard, C., Paech, F., Bouitbir, J. und Krähenbühl, S. (2018) «Mechanisms of toxicity associated with six tyrosine kinase inhibitors in human hepatocyte cell lines», Journal of applied toxicology : JAT. John Wiley And Sons, 38(3), S. 418-431. doi: 10.1002/jat.3551.   edoc
Paech, F., Mingard, C., Grünig, D., Abegg, V. F., Bouitbir, J. und Krähenbühl, S. (2018) «Mechanisms of mitochondrial toxicity of the kinase inhibitors ponatinib, regorafenib and sorafenib in human hepatic HepG2 cells», Toxicology. Elsevier, 395, S. 34-44. doi: 10.1016/j.tox.2018.01.005.   edoc
Paech, F., Abegg, V. F., Duthaler, U., Terracciano, L., Bouitbir, J. und Krähenbühl, S. (2018) «Sunitinib induces hepatocyte mitochondrial damage and apoptosis in mice», Toxicology. Elsevier, 409, S. 13-23. doi: 10.1016/j.tox.2018.07.009.   edoc
Bal-Price, A., Crofton, K. M., Leist, M., Allen, S., Arand, M., Buetler, T., Delrue, N., FitzGerald, R. E., Hartung, T., Heinonen, T., Hogberg, H., Bennekou, S. H., Lichtensteiger, W., Oggier, D., Paparella, M., Axelstad, M., Piersma, A., Rached, E., Schilter, B., Schmuck, G., Stoppini, L., Tongiorgi, E., Tiramani, M., Monnet-Tschudi, F., Wilks, M. F., Ylikomi, T. und Fritsche, E. (2018) «International STakeholder NETwork (ISTNET): creating a developmental neurotoxicity (DNT) testing road map for regulatory purposes», Archives of Toxicology. Springer, 89(2), S. 269-287. doi: 10.1007/s00204-015-1464-2.   edoc
Bal-Price, A., Hogberg, H. T., Crofton, K. M., Daneshian, M., FitzGerald, R. E., Fritsche, E., Heinonen, T., Hougaard Bennekou, S., Klima, S., Piersma, A. H., Sachana, M., Shafer, T. J., Terron, A., Monnet-Tschudi, F., Viviani, B., Waldmann, T., Westerink, R. H. S., Wilks, M. F., Witters, H., Zurich, M.-G. und Leist, M. (2018) «Recommendation on test readiness criteria for new approach methods in toxicology: Exemplified for developmental neurotoxicity», ALTEX. Springer Spektrum, 35(3), S. 306-352. doi: 10.14573/altex.1712081.   edoc
Sanvido, O., Schmid, K., FitzGerald, R. E., Roth, N., Wilks, M. F., Bormann, P. und Hopf, N. B. (2018) «A quantitative risk assessment for skin sensitizing plant protection products: Linking derived No-Effect levels (DNELs) with agricultural exposure models», Regulatory toxicology and pharmacology. Elsevier, 98, S. 171-183. doi: 10.1016/j.yrtph.2018.07.022.   edoc
Mühlebach, S., Haudenschild, U. und Schäublin, M. (2018) «Supply diruptions of essential drugs: a reporting platform based on a public-private-partnership to prevent and overcome shortages in Switzerland», Die pharmazeutische Industrie. Editio Cantor , 50(5), S. 594-601.   edoc
Hersberger, K. E. (2018) «Part VI Pharmaceutical Care for Specific Patient Groups », The Pharmacist Guide to Implementing Pharmaceutical Care. Springer, S. 295-296. Verfügbar unter: https://link.springer.com/content/pdf/bfm%3A978-3-319-92576-9%2F6%2F1.pdf.   edoc
Danton, O., Alexander, L., Hunlun, C., de Beer, D., Hamburger, M. und Joubert, E. (2018) «Bitter taste impact and thermal conversion of a naringenin glycoside isolated from Cyclopia genistoides», Journal of natural products. American Society of Pharmacognosy, 81(12), S. 2743-2749. doi: 10.1021/acs.jnatprod.8b00710.   edoc
Don, C. G. und Smieško, M. (2018) «Out-compute drug side effects: Focus on cytochrome P450 2D6 modeling», Wiley interdisciplinary reviews; computational molecular science. Wiley, 8(5), S. e1366. doi: 10.1002/wcms.1366.   edoc
Smieško, M., Don, C. G., Meuwly, R., Kucsera, S. und Brüschweiler, B. J. (2018) «Large-scale in silico screening of compounds contained in printing inks for food packaging materials», Toxicology Letters. Elsevier, 295, S. S96. doi: 10.1016/j.toxlet.2018.06.594.   edoc
Wimmersberger, D., Coulibaly, J. T., Schulz, J. D., Puchkov, M., Huwyler, J., N’Gbesso, Y., Hattendorf, J. und Keiser, J. (2018) «Efficacy and Safety of Ivermectin Against Trichuris trichiura in Preschool-aged and School-aged Children: A Randomized Controlled Dose-finding Trial», Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 67(8), S. 1247-1255. doi: 10.1093/cid/ciy246.   edoc
Mohebbi, M., Bararjanian, M., Ebrahimi, S. N., Smiesko, M. und Salehi, P. (2018) «Noscapine Derivatives as New Chiral Catalysts in Asymmetric Synthesis: Highly Enantioselective Addition of Diethylzinc to Aldehydes», SYNTHESIS-STUTTGART. GEORG THIEME VERLAG KG, 50(9), S. 1841-1848. doi: 10.1055/s-0037-1609224.   edoc
Malagnino, V., Hussner, J., Seibert, I., Stolzenburg, A., Sager, C. P. und Meyer zu Schwabedissen, H. E. (2018) «LST-3TM12 is a member of the OATP1B family and a functional transporter», Biochemical pharmacology, 148, S. 75-87. doi: 10.1016/j.bcp.2017.12.012.   edoc
Yuan, X., Yang, M., Chen, X., Zhang, X., Sukhadia, S., Musolino, N., Bao, H., Chen, T., Xu, C., Wang, Q., Santoro, S., Ricklin, D., Hu, J., Lin, R., Yang, W., Li, Z., Qin, W., Zhao, A., Scholler, N. und Coukos, G. (2018) «Correction to: Characterization of the first fully human anti-TEM1 scFv in models of solid tumor imaging and immunotoxin-based therapy», Cancer immunology, immunotherapy : CII, 67(2), S. 329-339. doi: 10.1007/s00262-017-2101-0.   edoc
Ditter, D., Mahler, H.-C., Gohlke, L., Nieto, A., Roehl, H., Huwyler, J., Wahl, M. und Allmendinger, A. (2018) «Impact of Vial Washing and Depyrogenation on Surface Properties and Delamination Risk of Glass Vials», Pharmaceutical research, 35(7), S. 146. doi: 10.1007/s11095-018-2421-6.   edoc
Boll, B., Josse, L., Heubach, A., Hochenauer, S., Finkler, C., Huwyler, J. und Koulov, A. V. (2018) «Impact of non-ideal analyte behavior on the separation of protein aggregates by asymmetric flow field-flow fractionation», Journal of Separation Science, 41(13), S. 2854-2864. doi: 10.1002/jssc.201701457.   edoc
Zihlmann, P., Silbermann, M., Sharpe, T., Jiang, X., Mühlethaler, T., Jakob, R. P., Rabbani, S., Sager, C. P., Frei, P., Pang, L., Maier, T. und Ernst, B. (2018) «KinITC-One Method Supports both Thermodynamic and Kinetic SARs as Exemplified on FimH Antagonists », Chemistry (Weinheim an der Bergstrasse, Germany), 24(49), S. 1-10. doi: 10.1002/chem.201802599.   edoc
Siegrist, S., Cörek, E., Detampel, P., Sandström, J., Wick, P. und Huwyler, J. (2018) «Preclinical hazard evaluation strategy for nanomedicines», Nanotoxicology, 13(1), S. 1-27. doi: 10.1080/17435390.2018.1505000.   edoc
Fischer, A., Don, C. G. und Smieško, M. (2018) «Molecular Dynamics Simulations Reveal Structural Differences among Allelic Variants of Membrane-Anchored Cytochrome P450 2D6», Journal of chemical information and modeling. American Chemical Society, 58(9), S. 1962-1975. doi: 10.1021/acs.jcim.8b00080.   edoc
Sánchez-Corral, P., Pouw, R. B., López-Trascasa, M. und Józsi, M. (2018) «Self-Damage Caused by Dysregulation of the Complement Alternative Pathway: Relevance of the Factor H Protein Family», Frontiers in immunology, 9, S. 1607. doi: 10.3389/fimmu.2018.01607.   edoc
Teumer, A., Chaker, L., Groeneweg, S., Li, Y., Di Munno, C., Barbieri, C., Schultheiss, U. T., Traglia, M., Ahluwalia, T. S., Akiyama, M., Appel, E. V. R., Arking, D. E., Arnold, A., Astrup, A., Beekman, M., Beilby, J. P., Bekaert, S., Boerwinkle, E., Brown, S. J., De Buyzere, M., Campbell, P. J., Ceresini, G., Cerqueira, C., Cucca, F., Deary, I. J., Deelen, J., Eckardt, K.-U., Ekici, A. B., Eriksson, J. G., Ferrrucci, L., Fiers, T., Fiorillo, E., Ford, I., Fox, C. S., Fuchsberger, C., Galesloot, T. E., Gieger, C., Gögele, M., De Grandi, A., Grarup, N., Greiser, K. H., Haljas, K., Hansen, T., Harris, S. E., van Heemst, D., den Heijer, M., Hicks, A. A., den Hollander, W., Homuth, G., Hui, J., Ikram, M. A., Ittermann, T., Jensen, R. A., Jing, J., Jukema, J. W., Kajantie, E., Kamatani, Y., Kasbohm, E., Kaufman, J.-M., Kiemeney, L. A., Kloppenburg, M., Kronenberg, F., Kubo, M., Lahti, J., Lapauw, B., Li, S., Liewald, D. C. M., Lifelines Cohort Study, Lim, E. M., Linneberg, A., Marina, M., Mascalzoni, D., Matsuda, K., Medenwald, D., Meisinger, C., Meulenbelt, I., De Meyer, T., Meyer Zu Schwabedissen, H. E., Mikolajczyk, R., Moed, M., Netea-Maier, R. T., Nolte, I. M., Okada, Y., Pala, M., Pattaro, C., Pedersen, O., Petersmann, A., Porcu, E., Postmus, I., Pramstaller, P. P., Psaty, B. M., Ramos, Y. F. M., Rawal, R., Redmond, P., Richards, J. B., Rietzschel, E. R., Rivadeneira, F., Roef, G., Rotter, J. I., Sala, C. F., Schlessinger, D., Selvin, E., Slagboom, P. E., Soranzo, N., Sørensen, T. I. A., Spector, T. D., Starr, J. M., Stott, D. J., Taes, Y., Taliun, D., Tanaka, T., Thuesen, B., Tiller, D., Toniolo, D., Uitterlinden, A. G., Visser, W. E., Walsh, J. P., Wilson, S. G., Wolffenbuttel, B. H. R., Yang, Q., Zheng, H.-F., Cappola, A., Peeters, R. P., Naitza, S., Völzke, H., Sanna, S., Köttgen, A., Visser, T. J. und Medici, M. (2018) «Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation», Nature communications, 9(1), S. 4455. doi: 10.1038/s41467-018-06356-1.   edoc
Haeuser, C., Goldbach, P., Huwyler, J., Friess, W. und Allmendinger, A. (2018) «Imaging Techniques to Characterize Cake Appearance of Freeze-Dried Products», Journal of pharmaceutical sciences, 107(11), S. 2810-2822. doi: 10.1016/j.xphs.2018.06.025.   edoc
Wagner-Hattler, L., Schoelkopf, J., Huwyler, J. und Puchkov, M. (2018) «Stability investigation of FCC-based tablets for oral suspension with caffeine and oxantel pamoate as model drugs», Drug development and industrial pharmacy, 45(2), S. 1-9. doi: 10.1080/03639045.2018.1529784.   edoc
Arnet, I., Greenland, M., Knuiman, M. W., Rankin, J. M., Hung, J., Nedkoff, L., Briffa, T. G. und Sanfilippo, F. M. (2018) «Operationalization and validation of a novel method to calculate adherence to polypharmacy with refill data from the Australian pharmaceutical benefits scheme (PBS) database», Clinical Epidemiology, 10, S. 1181-1194. doi: 10.2147/CLEP.S153496.   edoc
Metaxas, C., Albert, V., Stahl, M., Hersberger, K. E. und Arnet, I. (2018) «Development and validation of a questionnaire to self-assess patient knowledge of direct oral anticoagulants (KODOA-test)», Drug Healthcare and Patient Safety, 10, S. 69-77. doi: 10.2147/DHPS.S152954.   edoc
Arnet, I., Holden, M., Antoniou, S. und iPact group (2018) «Evaluation of a prompt card for community pharmacists performing consultations with patients on anticoagulation - lessons learned», Pharmacy practice, 16(3), S. 1244. doi: 10.18549/PharmPract.2018.03.1244.   edoc
Arnet, I., Gudka, S., Salter, S., Hersberger, K. E. und Clifford, R. (2018) «Readiness of pharmacists and consumers for pharmacy-based chlamydia screening in Australia and Switzerland», Sexual and Reproductive Healthcare, 16, S. 138-153. doi: 10.1016/j.srhc.2018.03.006.   edoc
Porta, F., Ehrsam, D., Lengerke, C. und Meyer Zu Schwabedissen, H. E. (2018) «Synthesis and characterization of a PDMS-PMOXA based polymersomes sensitive to MMP-9 for application in breast cancer», Molecular pharmaceutics, 15((11), S. 4884-4897. doi: 10.1021/acs.molpharmaceut.8b00521.   edoc
Wahl, J. und Smieško, M. (2018) «Thermodynamic Insight into Effects of Water Displacement and Rearrangement upon Ligand Modification using Molecular Dynamics Simulations», ChemMedChem, 13(13), S. 1325-1335. doi: 10.1002/cmdc.201800093.   edoc
Meyer-Massetti, C., Hofstetter, V., Hedinger-Grogg, B., Meier, C. R. und Guglielmo, B. J. (2018) «Medication-related problems during transfer from hospital to home care: baseline data from Switzerland», International Journal of Clinical Pharmacy. Springer, 40(6), S. 1614-1620. doi: 10.1007/s11096-018-0728-3.   edoc

2017

Widmer, N., Schumacher, L., Meister, T., Krähenbühl, J.-M., Mühlebach, S. und Bonnabry, P. (2017) «Notfall- und Katastrophenpharmazie: Neues Schweizer Fachzentrum», PharmaJournal. Schweizer Apothekerzeitung. PharmaSuisse, 155(15), S. 14-17.   edoc | Open Access
Haegler, P., Grünig, D., Berger, B., Terracciano, L., Krähenbühl, S. und Bouitbir, J. (2017) «Hepatic Effects of Pharmacological Doses of Hydroxy-Cobalamin[c-lactam] in Mice», PLoS One. Public Library Science, 12(1), S. e0171026. doi: 10.1371/journal.pone.0171026.   edoc
Charles, A.-L., Guilbert, A.-S., Guillot, M., Talha, S., Lejay, A., Meyer, A., Kindo, M., Wolff, V., Bouitbir, J., Zoll, J. und Geny, B. (2017) «Muscles Susceptibility to Ischemia-Reperfusion Injuries Depends on Fiber Type Specific Antioxidant Level», Frontiers in physiology. Frontiers Media, 8, S. 52. doi: 10.3389/fphys.2017.00052.   edoc
Hartung, T., FitzGerald, R. E., Jennings, P., Mirams, G. R., Peitsch, M. C., Rostami-Hodjegan, A., Shah, I., Wilks, M. F. und Sturla, S. J. (2017) «Systems Toxicology: Real World Applications and Opportunities», Chemical research in toxicology. American Chemical Society (ACS) , 30(4), S. 870-882. doi: 10.1021/acs.chemrestox.7b00003.   edoc | Open Access
Brueckner, D., Krähenbühl, S., Zuber, U., Bonkat, G. und Braissant, O. (2017) «An alternative sterility assessment for parenteral drug products using isothermal microcalorimetry», Journal of Applied Microbiology, 123(3), S. 773-779. doi: 10.1111/jam.13520.   edoc
Krähenbühl, S. und Pichler, W. J. (2017) «Medikamentöse Hepatopathien - Drug-induced liver injury», Therapeutische Umschau. Hogrefe, 74(3), S. 123-130. doi: 10.1024/0040-5930/a000895.   edoc
Paech, F., Bouitbir, J. und Krähenbühl, S. (2017) «Hepatocellular Toxicity Associated with Tyrosine Kinase Inhibitors: Mitochondrial Damage and Inhibition of Glycolysis», Frontiers in Pharmacology. Frontiers Media, 8, S. 367. doi: 10.3389/fphar.2017.00367.   edoc
Barda, B., Sayasone, S., Phongluxa, K., Xayavong, S., Keoduangsy, K., Odermatt, P., Puchkov, M., Huwyler, J., Hattendorf, J. und Keiser, J. (2017) «Efficacy of Moxidectin Versus Ivermectin Against Strongyloides stercoralis Infections: A Randomized, Controlled Noninferiority Trial», Clinical Infectious Diseases. Oxford University Press, 65(2), S. 276-281. doi: 10.1093/cid/cix278.   edoc
Krähenbühl, S. (2017) «Importance of the skeletal muscle carnitine stores in fuel selection», The Journal of Physiology. Wiley, 595(17), S. 5727-5728. doi: 10.1113/JP274755.   edoc
Blaser, L., Hassna, H., Hofmann, S., Holbro, A., Haschke, M., Rätz Bravo, A., Zeller, A., Krähenbühl, S. und Taegtmeyer, A. (2017) «Leucopenia associated with metamizole: a case-control study», Swiss medical weekly. EMH Swiss Medical Publishers, 147, S. w14438. doi: 10.4414/smw.2017.14438.   edoc
Brueckner, D., Solokhina, A., Krähenbühl, S. und Braissant, O. (2017) «A combined application of tunable diode laser absorption spectroscopy and isothermal micro-calorimetry for calorespirometric analysis», Journal of Microbiological Methods. Elsevier, 139, S. 210-214. doi: 10.1016/j.mimet.2017.06.012.   edoc
Drago, S., Imboden, R., Schlatter, P., Buylaert, M., Krähenbühl, S. und Drewe, J. (2017) «Pharmacokinetics of Transdermal Etofenamate and Diclofenac in Healthy Volunteers», Basic and Clinical Pharmacology and Toxicology. Wiley, 121(5), S. 423-429. doi: 10.1111/bcpt.12818.   edoc
Grünig, D., Felser, A., Bouitbir, J. und Krähenbühl, S. (2017) «The catechol-O-methyltransferase inhibitors tolcapone and entacapone uncouple and inhibit the mitochondrial respiratory chain in HepaRG cells», Toxicology in Vitro. Elsevier, 42, S. 337-347. doi: 10.1016/j.tiv.2017.05.013.   edoc
Paech, F., Messner, S., Spickermann, J., Wind, M., Schmitt-Hoffmann, A.-H., Witschi, A. T., Howell, B. A., Church, R. J., Woodhead, J., Engelhardt, M., Krähenbühl, S. und Maurer, M. (2017) «Mechanisms of hepatotoxicity associated with the monocyclic β-lactam antibiotic BAL30072», Archives of Toxicology. Springer, 91(11), S. 3647-3662. doi: 10.1007/s00204-017-1994-x.   edoc
Haegler, P., Joerin, L., Krähenbühl, S. und Bouitbir, J. (2017) «Hepatocellular Toxicity of Imidazole and Triazole Antimycotic Agents», Toxicological sciences. Oxford University Press, 157(1), S. 183-195. doi: 10.1093/toxsci/kfx029.   edoc
Brueckner, D., Roesti, D., Zuber, U., Sacher, M., Duncan, D., Krähenbühl, S. und Braissant, O. (2017) «Tunable diode laser absorption spectroscopy as method of choice for non-invasive and automated detection of microbial growth in media fills», Talanta. Elsevier, 167, S. 21-29. doi: 10.1016/j.talanta.2017.01.088.   edoc
Randazzo, G. M., Tonoli, D., Strajhar, P., Xenarios, I., Odermatt, A., Boccard, J. und Rudaz, S. (2017) «Enhanced metabolite annotation via dynamic retention time prediction: Steroidogenesis alterations as a case study», Journal of Chromatography B. Elsevier, 1071, S. 11-18. doi: 10.1016/j.jchromb.2017.04.032.   edoc
Jiménez-Canino, R., Lorenzo-Díaz, F., Odermatt, A., Bailey, M. A., Livingstone, D. E. W., Jaisser, F., Farman, N. und Alvarez de la Rosa, D. (2017) «11β-HSD2 SUMOylation Modulates Cortisol-Induced Mineralocorticoid Receptor Nuclear Translocation Independently of Effects on Transactivation», Endocrinology. Oxford University Press, 158(11), S. 4047-4063. doi: 10.1210/en.2017-00440.   edoc
Brecht, K., Riebel, V., Couttet, P., Paech, F., Wolf, A., Chibout, S.-D., Pognan, F., Krähenbühl, S. und Uteng, M. (2017) «Mechanistic insights into selective killing of OXPHOS-dependent cancer cells by arctigenin», Toxicology in Vitro. Elsevier, 40, S. 55-65. doi: 10.1016/j.tiv.2016.12.001.   edoc
Aeberhard , C. und Mühlebach, S. (2017) «Parenterale Ernährung - Grundlagen und Durchführung (Parenteral nutrition - basics and good practice)», Aktuelle Ernährungsmedizin, 42(1), S. 53-76. doi: 10.1055/s-0042-121786.   edoc
Astier, A., Barton Pai, A., Bissig, M., Crommelin, D. J. A., Flühmann, B., Hecq, J.-D., Knoeff, J., Lipp, H.-P., Morell-Baladrón, A. und Mühlebach, S. (2017) «How to select a nanosimilar», Annals of the New York Academy of Sciences, 1407(1), S. 50-62. doi: 10.1111/nyas.13382.   edoc
Hussaarts, L., Mühlebach, S., Shah, V. P., McNeil, S., Borchard, G., Flühmann, B., Weinstein, V., Neervannan, S., Griffiths, E., Jiang, W., Wolff-Holz, E., Crommelin, D. J. A. und de Vlieger, J. S. B. (2017) «Equivalence of complex drug products: advances in and challenges for current regulatory frameworks», Annals of the New York Academy of Sciences, 1407(1), S. 39-49. doi: 10.1111/nyas.13347.   edoc
Aeberhard, C., Steuer, C., Saxer, C., Huber, A., Stanga, Z. und Mühlebach, S. (2017) «Physicochemical stability and compatibility testing of levetiracetam in all-in-one parenteral nutrition admixtures in daily practice», European journal of pharmaceutical sciences, 96, S. 449-455. doi: 10.1016/j.ejps.2016.10.015.   edoc
Arends, J., Bachmann, P., Baracos, V., Barthelemy, N., Bertz, H., Bozzetti, F., Fearon, K., Hütterer, E., Isenring, E., Kaasa, S., Krznaric, Z., Laird, B., Larsson, M., Laviano, A., Mühlebach, S., Muscaritoli, M., Oldervoll, L., Ravasco, P., Solheim, T., Strasser, F., de van der Schueren, M. und Preiser, J.-C. (2017) «ESPEN guidelines on nutrition in cancer patients», Clinical nutrition, 36(1), S. 11-48. doi: 10.1016/j.clnu.2016.07.015.   edoc
Engeli, R. T., Tsachaki, M., Hassan, H. A., Sager, C. P., Essawi, M. L., Gad, Y. Z., Kamel, A. K., Mazen, I. und Odermatt, A. (2017) «Biochemical Analysis of Four Missense Mutations in the HSD17B3 Gene Associated With 46,XY Disorders of Sex Development in Egyptian Patients», The journal of sexual medicine, 14(9), S. 1165-1174. doi: 10.1016/j.jsxm.2017.07.006.   edoc
Knöpfel, T., Pastor-Arroyo, E. M., Schnitzbauer, U., Kratschmar, D. V., Odermatt, A., Pellegrini, G., Hernando, N. und Wagner, C. A. (2017) «The intestinal phosphate transporter NaPi-IIb (Slc34a2) is required to protect bone during dietary phosphate restriction», Scientific reports, 7(1), S. 11018. doi: 10.1038/s41598-017-10390-2.   edoc
Dolder, P. C., Strajhar, P., Vizeli, P., Hammann, F., Odermatt, A. und Liechti, M. E. (2017) «Pharmacokinetics and Pharmacodynamics of Lisdexamfetamine Compared with D-Amphetamine in Healthy Subjects», Frontiers in pharmacology, 8, S. 617. doi: 10.3389/fphar.2017.00617.   edoc
van Beek, A. E., Pouw, R. B., Brouwer, M. C., van Mierlo, G., Geissler, J., Ooijevaar-de Heer, P., de Boer, M., van Leeuwen, K., Rispens, T., Wouters, D. und Kuijpers, T. W. (2017) «Factor H-Related (FHR)-1 and FHR-2 Form Homo- and Heterodimers, while FHR-5 Circulates Only As Homodimer in Human Plasma», Frontiers in Immunology. Frontiers Media, 8, S. 1328. doi: 10.3389/fimmu.2017.01328.   edoc
Engeli, R. T., Rohrer, S. R., Vuorinen, A., Herdlinger, S., Kaserer, T., Leugger, S., Schuster, D. und Odermatt, A. (2017) «Interference of Paraben Compounds with Estrogen Metabolism by Inhibition of 17β-Hydroxysteroid Dehydrogenases», International Journal of Molecular Sciences, 18(9), S. 1-13. doi: 10.3390/ijms18092007.   edoc | Open Access
Aghagolzadeh, P., Radpour, R., Bachtler, M., van Goor, H., Smith, E. R., Lister, A., Odermatt, A., Feelisch, M. und Pasch, A. (2017) «Hydrogen sulfide attenuates calcification of vascular smooth muscle cells via KEAP1/NRF2/NQO1 activation», Atherosclerosis, 265, S. 78-86. doi: 10.1016/j.atherosclerosis.2017.08.012.   edoc
Morgan, R. A., Beck, K. R., Nixon, M., Homer, N. Z. M., Crawford, A. A., Melchers, D., Houtman, R., Meijer, O. C., Stomby, A., Anderson, A. J., Upreti, R., Stimson, R. H., Olsson, T., Michoel, T., Cohain, A., Ruusalepp, A., Schadt, E. E., Björkegren, J. L. M., Andrew, R., Kenyon, C. J., Hadoke, P. W. F., Odermatt, A., Keen, J. A. und Walker, B. R. (2017) «Carbonyl reductase 1 catalyzes 20β-reduction of glucocorticoids, modulating receptor activation and metabolic complications of obesity», Scientific Reports, 7(1), S. 10633. doi: 10.1038/s41598-017-10410-1.   edoc | Open Access
Alesutan, I., Voelkl, J., Feger, M., Kratschmar, D. V., Castor, T., Mia, S., Sacherer, M., Viereck, R., Borst, O., Leibrock, C., Gawaz, M., Kuro-O, M., Pilz, S., Tomaschitz, A., Odermatt, A., Pieske, B., Wagner, C. A. und Lang, F. (2017) «Involvement Of Vascular Aldosterone Synthase In Phosphate-Induced Osteogenic Transformation Of Vascular Smooth Muscle Cells», Scientific Reports, 7(1), S. 2059. doi: 10.1038/s41598-017-01882-2.   edoc | Open Access
Monzel, J. V., Budde, T., Meyer zu Schwabedissen, H. E., Schwebe, M., Bien-Möller, S., Lütjohann, D., Kroemer, H. K., Jedlitschky, G. und Grube, M. (2017) «Doxorubicin enhance oxysterol levels resulting in a LXR-mediated upregulation of cardiac cholesterol transporters», Biochemical pharmacology, 144, S. 108-119. doi: 10.1016/j.bcp.2017.08.008.   edoc
Flesch, D., Cheung, S.-Y., Schmidt, J., Gabler, M., Heitel, P., Kramer, J., Kaiser, A., Hartmann, M., Lindner, M., Lüddens-Dämgen, K., Heering, J., Lamers, C., Lüddens, H., Wurglics, M., Proschak, E., Schubert-Zsilavecz, M. und Merk, D. (2017) «Nonacidic Farnesoid X Receptor Modulators», Journal of Medicinal Chemistry, 60(16), S. 7199-7205. doi: 10.1021/acs.jmedchem.7b00903.   edoc
Cramer, J. und Klebe, G. (2017) «An Allyl Protection and Improved Purification Strategy Enables the Synthesis of Functionalized Phosphonamidate Peptides», Synthesis. GEORG THIEME VERLAG KG, 49(8), S. 1857-1866. doi: 10.1055/s-0036-1588393.   edoc
Cramer, J., Krimmer, S. G., Fridh, V., Wulsdorf, T., Karlsson, R., Heine, A. und Klebe, G. (2017) «Elucidating the Origin of Long Residence Time Binding for Inhibitors of the Metalloprotease Thermolysin», ACS Chemical Biology, 12(1), S. 225-233. doi: 10.1021/acschembio.6b00979.   edoc
Cramer, J., Schiebel, J., Wulsdorf, T., Grohe, K., Najbauer, E. E., Ehrmann, F. R., Radeva, N., Zitzer, N., Linne, U., Linser, R., Heine, A. und Klebe, G. (2017) «A False-Positive Screening Hit in Fragment-Based Lead Discovery: Watch out for the Red Herring», Angewandte Chemie (International Edition), 56(7), S. 1908-1913. doi: 10.1002/anie.201609824.   edoc
Cramer, J., Krimmer, S. G., Heine, A. und Klebe, G. (2017) «Paying the Price of Desolvation in Solvent-Exposed Protein Pockets: Impact of Distal Solubilizing Groups on Affinity and Binding Thermodynamics in a Series of Thermolysin Inhibitors», Journal of Medicinal Chemistry, 60(13), S. 5791-5799. doi: 10.1021/acs.jmedchem.7b00490.   edoc
Krimmer, S. G., Cramer, J., Schiebel, J., Heine, A. und Klebe, G. (2017) «How Nothing Boosts Affinity: Hydrophobic Ligand Binding to the Virtually Vacated S1′ Pocket of Thermolysin», Journal of the American Chemical Society, 139(30), S. 10419-10431. doi: 10.1021/jacs.7b05028.   edoc
Zhang, P., Hevey, R. und Ling, C.-C. (2017) «Total Synthesis of β-d-ido-Heptopyranosides Related to Capsular Polysaccharides of Campylobacter jejuni HS:4», The Journal of Organic Chemistry, 82(18), S. 9662-9674. doi: 10.1021/acs.joc.7b01752.   edoc

2016

Moradi-Afrapoli, F., Oufir, M., Walter, F. R., Deli, M. A., Smieško, M., Zabela, V., Butterweck, V. und Hamburger, M. (2016) «Validation of UHPLC-MS/MS methods for the determination of kaempferol and its metabolite 4-hydroxyphenyl acetic acid, and application to in vitro BBB and intestinal drug permeability studies», Journal of Pharmaceutical and Biomedical Analysis. Elsevier, 128, S. 264-274. doi: 10.1016/j.jpba.2016.05.039.   edoc
Jähne, E. A., Sampath, C., Butterweck, V., Hamburger, M. und Oufir, M. (2016) «Development and full validation of an UPLC-MS/MS method for the quantification of indirubin in rat plasma», Journal of Pharmaceutical and Biomedical Analysis. Elsevier, 128, S. 247-252. doi: 10.1016/j.jpba.2016.05.018.   edoc
Kettiger, H., Québatte, G., Perrone, B. und Huwyler, J. (2016) «Interactions between silica nanoparticles and phospholipid membranes», Biochimica et biophysica acta. Elsevier, 1858(9), S. 2163-2170. doi: 10.1016/j.bbamem.2016.06.023.   edoc
Hussner, J., Sünwoldt, J., Seibert, I., Gliesche, D. G. und Meyer zu Schwabedissen, H. E. (2016) «Pimecrolimus increases the expression of interferon-inducible genes that modulate human coronary artery cells proliferation», European Journal of Pharmacology. Elsevier, 784, S. 137-146. doi: 10.1016/j.ejphar.2016.05.020.   edoc
Buck, J., Huwyler, J., Kühl, P. und Dischinger, A. (2016) «Pediatric Dispersible Tablets: a Modular Approach for Rapid Prototyping», Pharmaceutical research. Plenum Press, 33(8), S. 2043-2055. doi: 10.1007/s11095-016-1946-9.   edoc
Preisig, D., Roth, R., Tognola, S., Varum, F. J. O., Bravo, R., Cetinkaya, Y., Huwyler, J. und Puchkov, M. (2016) «Mucoadhesive microparticles for local treatment of gastrointestinal diseases», European journal of pharmaceutics and biopharmaceutics. Elsevier, 105, S. 156-165. doi: 10.1016/j.ejpb.2016.06.009.   edoc
Gliesche, D. G., Hussner, J., Witzigmann, D., Porta, F., Glatter, T., Schmidt, A., Huwyler, J. und Meyer Zu Schwabedissen, H. E. (2016) «Secreted Matrix Metalloproteinase-9 of Proliferating Smooth Muscle Cells as a Trigger for Drug Release from Stent Surface Polymers in Coronary Arteries», Molecular Pharmaceutics. American Chemical Society, 13(7), S. 2290-2300. doi: 10.1021/acs.molpharmaceut.6b00033.   edoc
Bischoff, T., Vogl, C. R., Ivemeyer, S., Klarer, F., Meier, B., Hamburger, M. und Walkenhorst, M. (2016) «Plant and natural product based household remedies manufactured and used by farmers of six central Swiss cantons to treat livestock», Livestock science. Elsevier, 189, S. 110-125. doi: 10.1016/j.livsci.2016.05.003.   edoc
Hu, Z., Wahl, J., Hamburger, M. und Vedani, A. (2016) «Molecular mechanisms of endocrine and metabolic disruption: An in silico study on antitrypanosomal natural products and some derivatives», Toxicology Letters. Elsevier, 252, S. 29-41. doi: 10.1016/j.toxlet.2016.04.013.   edoc
Eigenmann, D. E., Dürig, C., Jähne, E. A., Smieško, M., Culot, M., Gosselet, F., Cecchelli, R., Cederberg Helms, H. C., Brodin, B., Wimmer, L., Mihovilovic, M. D., Hamburger, M. und Oufir, M. (2016) «In vitro blood-brain barrier permeability predictions of piperine analogues with GABAA receptor modulating properties», European Journal of Pharmaceutics and Biopharmaceutics. Elsevier, 103, S. 118-126. doi: 10.1016/j.ejpb.2016.03.029.   edoc
Witzigmann, D., Quagliata, L., Schenk, S. H., Quintavalle, C., Terracciano, L. M. und Huwyler, J. (2016) «Variable asialoglycoprotein-receptor 1 expression in liver disease: Implications for therapeutic intervention», Hepatology research . Blackwell, 46(7), S. 686-696. doi: 10.1111/hepr.12599.   edoc
Eberle, V. A., Häring, A., Schoelkopf, J., Gane, P. A. C., Huwyler, J. und Puchkov, M. (2016) «In silico and in vitro methods to optimize the performance of experimental gastroretentive floating mini-tablets», Drug development and industrial pharmacy. Informa Healthcare, 42(5), S. 808-817. doi: 10.3109/03639045.2015.1078350.   edoc
Canonica, J., Sergi, C., Maillard, M., Klusonova, P., Odermatt, A., Koesters, R., Loffing-Cueni, D., Loffing, J., Rossier, B., Frateschi, S. und Hummler, E. (2016) «Adult nephron-specific MR-deficient mice develop a severe renal PHA-1 phenotype», Pflügers Archiv : European journal of physiology. Springer, 468(5), S. 895-908. doi: 10.1007/s00424-015-1785-2.   edoc
Mani, O., Nashev, L. G., Livelo, C., Baker, M. E. und Odermatt, A. (2016) «Role of Pro-637 and Gln-642 in human glucocorticoid receptors and Ser-843 and Leu-848 in mineralocorticoid receptors in their differential responses to cortisol and aldosterone», The Journal of steroid biochemistry and molecular biology. Elsevier, 159, S. 31-40. doi: 10.1016/j.jsbmb.2016.02.017.   edoc
Riede, J., Poller, B., Umehara, K.- ichi, Huwyler, J. und Camenisch, G. (2016) «New IVIVE method for the prediction of total human clearance and relative elimination pathway contributions from in vitro hepatocyte and microsome data», European journal of pharmaceutical sciences. Elsevier, 86, S. 96-102. doi: 10.1016/j.ejps.2016.02.022.   edoc
Odermatt, A., Strajhar, P. und Engeli, R. T. (2016) «Disruption of steroidogenesis: Cell models for mechanistic investigations and as screening tools», The Journal of steroid biochemistry and molecular biology. Elsevier, 158, S. 9-21. doi: 10.1016/j.jsbmb.2016.01.009.   edoc
Grabe, H. J., Wittfeld, K., Van der Auwera, S., Janowitz, D., Hegenscheid, K., Habes, M., Homuth, G., Barnow, S., John, U., Nauck, M., Völzke, H., Meyer zu Schwabedissen, H. E., Freyberger, H. J. und Hosten, N. (2016) «Effect of the interaction between childhood abuse and rs1360780 of the FKBP5 gene on gray matter volume in a general population sample», Human brain mapping. Wiley-Liss, 37(4), S. 1602-1613. doi: 10.1002/hbm.23123.   edoc
Bloechliger, M., Ceschi, A., Rüegg, S., Kupferschmidt, H., Krähenbühl, S., Jick, S. S., Meier, C. R. und Bodmer, M. (2016) «Risk of Seizures Associated with Antidepressant Use in Patients with Depressive Disorder: Follow-up Study with a Nested Case-Control Analysis Using the Clinical Practice Research Datalink», Drug Safety . Springer, 39(4), S. 307-321. doi: 10.1007/s40264-015-0363-z.   edoc
Seliger, C., Meier, C. R., Jick, S. S., Uhl, M., Bogdahn, U., Hau, P. und Leitzmann, M. F. (2016) «Use of cardiac glycosides and risk of glioma», Journal of Neuro-Oncology . Springer Science+Business Media B.V., 127(2), S. 321-328. doi: 10.1007/s11060-015-2036-2.   edoc
Ramming, T., Kanemura, S., Okumura, M., Inaba, K. und Appenzeller-Herzog, C. (2016) «Cysteines 208 and 241 in Ero1α are required for maximal catalytic turnover», Redox biology. Elsevier, 7, S. 14-20. doi: 10.1016/j.redox.2015.11.004.   edoc
Strajhar, P., Schmid, Y., Liakoni, E., Dolder, P. C., Rentsch, K. M., Kratschmar, D. V., Odermatt, A. und Liechti, M. E. (2016) «Acute Effects of Lysergic Acid Diethylamide on Circulating Steroid Levels in Healthy Subjects», Journal of Neuroendocrinology. Wiley, 28(3), S. 12374. doi: 10.1111/jne.12374.   edoc | Open Access
Coqueiro, A., Choi, Y. H., Verpoorte, R., Sankar Gupta, K. B. S., De Mieri, M., Hamburger, M., Marx Young, M. C., Stapleton, P., Gibbons, S. und da Silva Bolzani, V. (2016) «Anti-staphylococcal prenylated acylphoroglucinol and xanthones from Kielmeyera variabilis (Clusiaceae)», Journal of natural products. American Society of Pharmacognosy, 79(3), S. 470-476. doi: 10.1021/acs.jnatprod.5b00858.   edoc
Eigenmann, D. E., Jähne, E. A., Smiesko, M., Hamburger, M. und Oufir, M. (2016) «Validation of an immortalized human (hBMEC) in vitro blood-brain barrier model», Analytical and Bioanalytical Chemistry. Springer, 408(8), S. 2095-2107. doi: 10.1007/s00216-016-9313-6.   edoc
Seliger, C., Ricci, C., Meier, C. R., Bodmer, M., Jick, S. S., Bogdahn, U., Hau, P. und Leitzmann, M. F. (2016) «Diabetes, use of antidiabetic drugs, and the risk of glioma», Neuro-Oncology. Oxford University Press, 18(3), S. 340-349. doi: 10.1093/neuonc/nov100.   edoc | Open Access
Bornand, D., Toovey, S., Jick, S. S. und Meier, C. R. (2016) «The risk of new onset depression in association with influenza - a population-based observational study», Brain, Behavior and Immunity . Elsevier, 53, S. 131-137. doi: 10.1016/j.bbi.2015.12.005.   edoc
Requena, G., Huerta, C., Gardarsdottir, H., Logie, J., González-González, R., Abbing-Karahagopian, V., Miret, M., Schneider, C., Souverein, P. C., Webb, D., Afonso, A., Boudiaf, N., Martin, E., Oliva, B., Alvarez, A., De Groot, M. C. H., Bate, A., Johansson, S., Schlienger, R., Reynolds, R., Klungel, O. H. und de Abajo, F. J. (2016) «Hip/femur fractures associated with the use of benzodiazepines (anxiolytics, hypnotics and related drugs): a methodological approach to assess consistencies across databases from the PROTECT-EU project», Pharmacoepidemiology and drug safety. Wiley, 25(1), S. 66-78. doi: 10.1002/pds.3816.   edoc
Huerta, C., Abbing-Karahagopian, V., Requena, G., Oliva, B., Alvarez, Y., Gardarsdottir, H., Miret, M., Schneider, C., Gil, M., Souverein, P. C., De Bruin, M. L., Slattery, J., De Groot, M. C. H., Hesse, U., Rottenkolber, M., Schmiedl, S., Montero, D., Bate, A., Ruigomez, A., García-Rodríguez, L. A., Johansson, S., de Vries, F., Schlienger, R. G., Reynolds, R. F., Klungel, O. H. und de Abajo, F. J. (2016) «Exposure to benzodiazepines (anxiolytics, hypnotics and related drugs) in seven European electronic healthcare databases: a cross-national descriptive study from the PROTECT-EU Project», Pharmacoepidemiology and drug safety. John Wiley, 25(1), S. 56-65. doi: 10.1002/pds.3825.   edoc
Spoendlin, J., Karatas, G., Furlano, R. I., Jick, S. S. und Meier, C. R. (2016) «Rosacea in Patients with Ulcerative Colitis and Crohn’s Disease: a Population-based Case-control Study», Inflammatory Bowel Diseases. Lippincott Williams & Wilkins, 22(3), S. 680-687. doi: 10.1097/MIB.0000000000000644.   edoc
Corradi, E., De Mieri, M., Cadisch, L., Abbet, C., Hamburger, M. und Potterat, O. (2016) «New Acylated Flavonol Glycosides and a Phenolic Profile of Pritzelago alpina, a Forgotten Edible Alpine Plant », Chemistry & Biodiversity. Helvetica Chimica Acta, 13(2), S. 188-197. doi: 10.1002/cbdv.201500353.   edoc
Ríos Quiroz, A., Lamerz, J., De Cunha, T., Boillon, A., Adler, M., Finkler, C., Huwyler, J., Schmidt, R., Mahler, H.-C. und Koulov, A. V. (2016) «Factors Governing the Precision of Subvisible Particle Measurement Methods - A Case Study with a Low-Concentration Therapeutic Protein Product in a Prefilled Syringe», Pharmaceutical research. Springer, 33(2), S. 450-461. doi: 10.1007/s11095-015-1801-4.   edoc
Wilson, J. C., Furlano, R. I., Jick, S. S. und Meier, C. R. (2016) «Inflammatory Bowel Disease and the Risk of Autoimmune Diseases», Journal of Crohn’s and Colitis. Elsevier, 10(2), S. 186-193. doi: 10.1093/ecco-jcc/jjv193.   edoc
Mathaes, R., Mahler, H.-C., Buettiker, J.-P., Roehl, H., Lam, P., Brown, H., Luemkemann, J., Adler, M., Huwyler, J., Streubel, A. und Mohl, S. (2016) «The pharmaceutical vial capping process; Container closure systems, capping equipment, regulatory framework, and seal quality tests», European journal of pharmaceutics and biopharmaceutics. Elsevier, 99, S. 54-64. doi: 10.1016/j.ejpb.2015.11.016.   edoc
Rizner, T. L., Sasano, H., Choi, M. H., Odermatt, A. und Adamski, J. (2016) «Recommendations for description and validation for antibodies for research use», The journal of steroid biochemistry and molecular biology. Pergamon, 156, S. 40-42. doi: 10.1016/j.jsbmb.2015.11.021.   edoc
Mancuso, R. V., Welzenbach, K., Steinberger, P., Krähenbühl, S. und Weitz-Schmidt, G. (2016) «Downstream effect profiles discern different mechanisms of integrin αLβ2 inhibition», Biochemical Pharmacology. Elsevier, 119, S. 42-55. doi: 10.1016/j.bcp.2016.09.002.   edoc
Mühlebach , S. F. (2016) «Arzneimittel bei HomeCare-Ernährung: Gibt es pharmazeutisches Optimierungspotenzial? (Drug and nutrition in the home care setting: is there potential for pharmaceutical improvement », Aktuel Ernahrungsmed. Georg Thieme, 41(3), S. 190-195. doi: 10.1055/s-0042-105715.   edoc
de Vlieger , J. S. B., Borchard, G., Shah, V. P., Flühmann, B., Neervannan, S. und Mühlebach , S. F. (2016) «Is the EU ready for non-biological complex drug products?», Generics and biosimilars initiative journal, 5(3), S. 101-102. doi: 10.5639/gabij.2016.0503.026.   edoc
Bouitbir, J., Singh, F., Charles, A.-L., Schlagowski, A.-I., Bonifacio, A., Echaniz-Laguna, A., Geny, B., Krahenbuhl, S. und Zoll, J. (2016) «Statins Trigger Mitochondrial Reactive Oxygen Species-Induced Apoptosis in Glycolytic Skeletal Muscle», Antioxidants and Redox Signaling. Mary Ann Liebert, 24(2), S. 84-98. doi: 10.1089/ars.2014.6190.   edoc
Bouitbir, J., Haegler, P., Singh, F., Joerin, L., Felser, A., Duthaler, U. und Krähenbühl, S. (2016) «Impaired Exercise Performance and Skeletal Muscle Mitochondrial Function in Rats with Secondary Carnitine Deficiency», Frontiers in Physiology. Frontiers Media, 7, S. 345. doi: 10.3389/fphys.2016.00345.   edoc
Krimmer, S. G., Cramer, J., Betz, M., Fridh, V., Karlsson, R., Heine, A. und Klebe, G. (2016) «Rational Design of Thermodynamic and Kinetic Binding Profiles by Optimizing Surface Water Networks Coating Protein-Bound Ligands», Journal of medicinal chemistry, 59(23), S. 10530-10548. doi: 10.1021/acs.jmedchem.6b00998.   edoc
Lamers, C., Merk, D., Gabler, M., Flesch, D., Kaiser, A. und Schubert-Zsilavecz, M. (2016) «SAR studies on FXR modulators led to the discovery of the first combined FXR antagonistic/TGR5 agonistic compound», Future medicinal chemistry, 8(2), S. 133-148. doi: 10.4155/fmc.15.178.   edoc

2015

Kettiger, H., Karaman, D. S., Schiesser, L., Rosenholm, J. M. und Huwyler, J. (2015) «Comparative safety evaluation of silica-based particles», Toxicology in vitro. Elsevier, 30(1), S. 355-363. doi: 10.1016/j.tiv.2015.09.030.   edoc
Moghadam, S. E., Ebrahimi, S. N., Gafner, F., Ochola, J. B., Marubu, R. M., Lwande, W., Frei Haller, B., Salehi, P. und Hamburger, M. (2015) «Metabolite profiling for caffeic acid oligomers in Satureja biflora», Industrial Crops and Products. Elsevier, 76, S. 892-899. doi: 10.1016/j.indcrop.2015.07.059.   edoc
Arnet, I., Altermatt, M., Roggo, Y. und Schnetzler, G. (2015) «Pharmaceutical quality of eight generics of ceftriaxone preparation for injection in Eastern Asia», Journal of chemotherapy . Taylor & Francis Group, 27(6), S. 337-342. doi: 10.1179/1973947814Y.0000000208.   edoc
Bruderer, S. G., Bodmer, M., Jick, S. S. und Meier, C. R. (2015) «Association of hormone therapy and incident gout: population-based case-control study», Menopause. Lippincott, 22(12), S. 1335-1342. doi: 10.1097/GME.0000000000000474.   edoc
Favre-Godal, Q., Dorsaz, S., Queiroz, E. F., Marcourt, L., Ebrahimi, S. N., Allard, P.-M., Voinesco, F., Hamburger, M., Gupta, M. P., Gindro, K., Sanglard, D. und Wolfender, J.-L. (2015) «Identification of novel anti-Candida cassane type diterpenes from the roots bark of Swartzia simplex (Sw.) Spreng», Journal of Natural Products. American Chemical Society, 78(12), S. 2994-3004. doi: 10.1021/acs.jnatprod.5b00744.   edoc
Arnet, I., Seidling, H. M. und Hersberger, K. E. (2015) «Unerwünschte Arzneimittelwirkungen in der Offizinapotheke», Therapeutische Umschau. Hans Huber, 72(11/12), S. 687-692. doi: 10.1024/0040-5930/a000738.   edoc
Folzer, E., Khan, T., Schmidt, R., Finkler, C., Huwyler, J., Mahler, H.-C. und Koulov, A. V. (2015) «Determination of the Density of Protein Particles Using a Suspended Microchannel Resonator», Journal of pharmaceutical sciences. American Pharmaceutical Association, 104(12), S. 4034-4040. doi: 10.1002/jps.24635.   edoc
Boll, B., Folzer, E., Finkler, C., Huwyler, J., Mahler, H.-C., Schmidt, R. und Koulov, A. V. (2015) «Comparative Evaluation of Two Methods for Preparative Fractionation of Proteinaceous Subvisible Particles-Differential Centrifugation and FACS», Pharmaceutical research. Springer, 32(12), S. 3952-3964. doi: 10.1007/s11095-015-1755-6.   edoc
Kaserer, T., Beck, K., Akram, M., Odermatt, A. und Schuster, D. (2015) «Pharmacophore models and pharmacophore-based virtual screening: concepts and applications exemplified on hydroxysteroid dehydrogenases», Molecules. MDPI, 20(12), S. 22799-22832. doi: 10.3390/molecules201219880.   edoc
Shelton, L. M., Lister, A., Walsh, J., Jenkins, R. E., Wong, M. H. L., Rowe, C., Ricci, E., Ressel, L., Fang, Y., Demougin, P., Vukojevic, V., O’Neill, P. M., Goldring, C. E., Kitteringham, N. R., Park, B. K., Odermatt, A. und Copple, I. M. (2015) «Integrated transcriptomic and proteomic analyses uncover regulatory roles of Nrf2 in the kidney», Kidney international. Springer, 88(6), S. 1261-1273. doi: 10.1038/ki.2015.286.   edoc
Becker, C., Wilson, J. C., Jick, S. S. und Meier, C. R. (2015) «Non-steroidal anti-inflammatory drugs and the risk of head and neck cancer: a case-control analysis», International journal of cancer. Alan R. Liss, 137(10), S. 2424-2431. doi: 10.1002/ijc.29601.   edoc
Seibert, J. K., Quagliata, L., Quintavalle, C., Hammond, T. G., Terracciano, L. und Odermatt, A. (2015) «A role for the dehydrogenase DHRS7 (SDR34C1) in prostate cancer», Cancer medicine. Wiley, 4(11), S. 1717-1729. doi: 10.1002/cam4.517.   edoc
Di Chiara, M., Glaudemans, B., Loffing-Cueni, D., Odermatt, A., Al-Hasani, H., Devuyst, O., Faresse, N. und Loffing, J. (2015) «Rab-GAP TBC1D4 (AS160) is dispensable for the renal control of sodium and water homeostasis but regulates GLUT4 in mouse kidney», American journal of physiology. Gastrointestinal and liver physiology. American Physiological Society, 309(9), S. F779-F790. doi: 10.1152/ajprenal.00139.2015.   edoc
Becker, C., Jick, S. S., Meier, C. R. und Bodmer, M. (2015) «No evidence for a decreased risk of thyroid cancer in association with use of metformin or other antidiabetic drugs: a case-control study», BMC cancer. BioMed Central, 15, S. 719. doi: 10.1186/s12885-015-1719-6.   edoc
Haegler, P., Grünig, D., Berger, B., Krähenbühl, S. und Bouitbir, J. (2015) «Impaired mitochondrial function in HepG2 cells treated with hydroxy-cobalamin[c-lactam]: a cell model for idiosyncratic toxicity», Toxicology. Elsevier, 336, S. 48-58. doi: 10.1016/j.tox.2015.07.015.   edoc
Imfeld, P., Bodmer, M., Jick, S. S. und Meier, C. R. (2015) «Benzodiazepine Use and Risk of Developing Alzheimer’s Disease or Vascular Dementia: A Case-Control Analysis», Drug safety. Adis International, 38(10), S. 909-919. doi: 10.1007/s40264-015-0319-3.   edoc
Glanzmann, C., Frey, B., Meier, C. R. und Vonbach, P. (2015) «Analysis of medication prescribing errors in critically ill children», European journal of pediatrics. Springer, 174(10), S. 1347-1355. doi: 10.1007/s00431-015-2542-4.   edoc
Allmendinger, A., Mueller, R., Huwyler, J., Mahler, H.-C. und Fischer, S. (2015) «Sterile Filtration of Highly Concentrated Protein Formulations: Impact of Protein Concentration, Formulation Composition, and Filter Material», Journal of pharmaceutical sciences. American Pharmaceutical Association, 104(10), S. 3319-3329. doi: 10.1002/jps.24561.   edoc
Farimani, M. M., Bahadori, M. B., Koulaei, S. A., Salehi, P., Ebrahimi, S. N., Khavasi, H. R. und Hamburger, M. (2015) «New ursane triterpenoids from Salvia urmiensis Bunge: absolute configuration and anti-proliferative activity», Fitoterapia. Elsevier, 106, S. 1-6. doi: 10.1016/j.fitote.2015.07.017.   edoc
Du, K., De Mieri, M., Neuburger, M., Zietsman, P. C., Marston, A., van Vuuren, S. F., Ferreira, D., Hamburger, M. und van der Westhuizen, J. H. (2015) «Labdane and clerodane diterpenes from Colophospermum mopane», Journal of Natural Products. American Chemical Society, 78(10), S. 2494-2504. doi: 10.1021/acs.jnatprod.5b00729.   edoc
Bruderer, S. G., Bodmer, M., Jick, S. S. und Meier, C. R. (2015) «Poorly controlled type 2 diabetes mellitus is associated with a decreased risk of incident gout: a population-based case-control study», Annals of the rheumatic diseases. British Medical Association, 74(9), S. 1651-1658. doi: 10.1136/annrheumdis-2014-205337.   edoc
Werk, T., Huwyler, J., Hafner, M., Luemkemann, J. und Mahler, H.-C. (2015) «An Impedance-Based Method to Determine Reconstitution Time for Freeze-Dried Pharmaceuticals», Journal of pharmaceutical sciences. American Pharmaceutical Association, 104(9), S. 2948-2955. doi: 10.1002/jps.24443.   edoc
Folzer, E., Diepold, K., Bomans, K., Finkler, C., Schmidt, R., Bulau, P., Huwyler, J., Mahler, H.-C. und Koulov, A. V. (2015) «Selective Oxidation of Methionine and Tryptophan Residues in a Therapeutic IgG1 Molecule», Journal of pharmaceutical sciences. American Pharmaceutical Association, 104(9), S. 2824-2831. doi: 10.1002/jps.24509.   edoc
Kunze, A., Poller, B., Huwyler, J. und Camenisch, G. (2015) «Application of the extended clearance concept classification system (ECCCS) to predict the victim drug-drug interaction potential of statins», Drug Metabolism and Personalized Therapy. de Gruyter, 30(3), S. 175-188. doi: 10.1515/dmdi-2015-0003.   edoc
Hussner, J., Begung, R., Boettcher, K., Gliesche, D. G., Prestin, K. und Meyer zu Schwabedissen, H. E. (2015) «Expression of OATP2B1 as determinant of drug effects in the microcompartment of the coronary artery», Vascular Pharmacology . Elsevier, 72, S. 25-34. doi: 10.1016/j.vph.2015.06.006.   edoc
Moridi Farimani, M., Abbas-Mohammadi, M., Esmaeili, M.-A., Salehi, P., Nejad-Ebrahimi, S., Sonboli, A. und Hamburger, M. (2015) «Seco-ursane type triterpenoids from Salvia urmiensis with apoptosis-inducing activity», Planta medica. Thieme, 81(14), S. 1290-1295. doi: 10.1055/s-0035-1546256.   edoc
Wilson, J. C., Toovey, S., Jick, S. S. und Meier, C. R. (2015) «Previously diagnosed influenza infections and the risk of developing epilepsy», Epidemiology and infection. Cambridge University Press, 143(11), S. 2408-2415. doi: 10.1017/S0950268814003380.   edoc
Bonifacio, A., Sanvee, G. M., Bouitbir, J. und Krähenbühl, S. (2015) «The AKT/mTOR signaling pathway plays a key role in statin-induced myotoxicity», Biochimica et biophysica acta. Molecular cell research. Elsevier, 1853(8), S. 1841-1849. doi: 10.1016/j.bbamcr.2015.04.010.   edoc
Roberts, P. A., Bouitbir, J., Bonifacio, A., Singh, F., Kaufmann, P., Urwyler, A. und Krähenbühl, S. (2015) «Contractile function and energy metabolism of skeletal muscle in rats with secondary carnitine deficiency», American Journal of Physiology. Endocrinology and Metabolism. American Physiological Society, 309(3), S. E265-E274. doi: 10.1152/ajpendo.00001.2015.   edoc
Liakoni, E., Rätz Bravo, A. E. und Krähenbühl, S. (2015) «Hepatotoxicity of New Oral Anticoagulants (NOACs)», Drug safety. Adis International, 38(8), S. 711-720. doi: 10.1007/s40264-015-0317-5.   edoc
Oufir, M., Seiler, C., Gerodetti, M., Gerber, J., Fürer, K., Mennet-von Eiff, M., Elsas, S.-M., Brenneisen, R., von Mandach, U., Hamburger, M. und Potterat, O. (2015) «Quantification of burfadienolides in bryophyllum pinnatum leaves and manufactured products by UHPLC-ESIMS/MS», Planta Medica. Georg Thieme Verlag, 81(12/13), S. 1190-1197. doi: 10.1055/s-0035-1546126.   edoc
Du, K., De Mieri, M., Saxena, P., Phungula, K. V., Zietsman, P. C., Hering, S., van der Westhuizen, J. H. und Hamburger, M. (2015) «HPLC-​Based Activity Profiling for hERG Channel Inhibitors in the South African Medicinal Plant Galenia africana», Planta Medica. Georg Thieme Verlag, 81(12/13), S. 1154-1162. doi: 10.1055/s-0035-1545929.   edoc
Allmendinger, A., Mueller, R., Schwarb, E., Chipperfield, M., Huwyler, J., Mahler, H.-C. und Fischer, S. (2015) «Measuring Tissue Back-Pressure - In Vivo Injection Forces During Subcutaneous Injection», Pharmaceutical research. Plenum Press, 32(7), S. 2229-2240. doi: 10.1007/s11095-014-1611-0.   edoc
Bloechliger, M., Rüegg, S., Jick, S. S., Meier, C. R. und Bodmer, M. (2015) «Antipsychotic drug use and the risk of seizures: follow-up study with a nested case-control analysis», CNS drugs. Springer, 29(7), S. 591-603. doi: 10.1007/s40263-015-0262-y.   edoc
Layton, J. B., Meier, C. R., Sharpless, J. L., Stürmer, T., Jick, S. S. und Brookhart, M. A. (2015) «Comparative Safety of Testosterone Dosage Forms», JAMA internal medicine. American Medical Association, 175(7), S. 1187-1196. doi: 10.1001/jamainternmed.2015.1573.   edoc
Ślusarczyk, S., Topolski, J., Domaradzki, K., Adams, M., Hamburger, M. und Matkowski, M. (2015) «Isolation and fast selective determinatino of nor-abhietanoid diterpenoids from Perovskia atriplicifolia roots using LC-ESIMS/MS with multiple reaction monitoring», Natural Product Communications . Natural Product Incorporation , 10(7), S. 1149-1152.   edoc
Odermatt, A. und Klusonova, P. (2015) «11β-Hydroxysteroid dehydrogenase 1: Regeneration of active glucocorticoids is only part of the story», The journal of steroid biochemistry and molecular biology. Pergamon, 151, S. 85-92. doi: 10.1016/j.jsbmb.2014.08.011.   edoc
Tsachaki, M., Birk, J., Egert, A. und Odermatt, A. (2015) «Determination of the topology of endoplasmic reticulum membrane proteins using redox-sensitive green-fluorescence protein fusions», Biochimica et biophysica acta. Molecular cell research. Elsevier, 1853(7), S. 1672-1682. doi: 10.1016/j.bbamcr.2015.04.002.   edoc
Reinau, D., Surber, C., Jick, S. S. und Meier, C. R. (2015) «Nonsteroidal anti-inflammatory drugs and the risk of nonmelanoma skin cancer», International Journal of Cancer. Wiley, 137(1), S. 144-153. doi: 10.1002/ijc.29357.   edoc
Preisig, D., Weingartner, M., Varum, F. J. O., Bravo, R., Alles, R., Huwyler, J. und Puchkov, M. (2015) «Marker-ion analysis for quantification of mucoadhesivity of microparticles in particle-retention assays», International journal of pharmaceutics. Elsevier, 487(1-2), S. 157-166. doi: 10.1016/j.ijpharm.2015.04.020.   edoc