Sina Rütschlin is a postdoctoral researcher who joined the University of Basel in 2024. Before, she earned her Bachelor's degree in Chemistry in 2013 from the University of Konstanz, Germany, focusing on new synthetic routes to furo[2,3-d]pyrimidines. In 2015, she completed her Master's degree at the same university, with her thesis included in the prestigious PhD Fast-Track program.

Sina obtained her PhD in 2019 from the University of Konstanz, where she investigated small molecule modulators of bacterial swarming behavior. Her doctoral work centered on drug discovery and particularly on the biosynthesis and application of new cyclic siderophores with novel core structures that inhibit pathogenic swarming bacteria.

Additionally, she participated in various collaborations that resulted for example in the identification of a neurodegenerative metabolite acting specifically against dopaminergic neurons in a Parkinson's disease cell model.

Currently, Sina´s research involves projects focusing on natural product biosynthesis in plants and the discovery of new lead structures for antibiotics, including joint projects with local industry.

Publication(s):

Ückert et al. (2023): Identification of the bacterial metabolite aerugine as potential trigger of human dopaminergic neurodegeneration. Environment International, 180, p. 108229. Available at: https://doi.org/10.1016/j.envint.2023.108229.

Rütschlin et al. (2017): One Enzyme, Three Metabolites: Shewanella algae controls siderophore production via the cellular substrate pool. Cell Chemical Biology, 24 (5), p. 598-604. Available at: https://doi.org/10.1016/j.chembiol.2017.03.017.

Rütschlin and Böttcher (2019): Inhibitors of bacterial swarming behavior. Chemistry Europe, 26 (5), p. 964-979. Available at: https://doi.org/10.1002/chem.201901961.