Publications

Bouitbir, J., Panajatovic, M. V., Frechard, T., Roos, N. J. und Krähenbühl, S. (2020) «Imatinib and Dasatinib Provoke Mitochondrial Dysfunction Leading to Oxidative Stress in C2C12 Myotubes and Human RD Cells», Frontiers in pharmacology, 11, S. 1106. doi: 10.3389/fphar.2020.01106.   
Panajatovic, M., Singh, F., Duthaler, U., Krähenbühl, S. und Bouitbir, J. (2020) «Role of PGC-1-alpha-associated Mitochondrial Biogenesis in Statin-induced Myotoxicity», European cardiology, 15, S. e35. doi: 10.15420/ecr.2020.15.1.PO12.   
Sanvee, G. M., Panajatovic, M., Bouitbir, D. J. und Krähenbühl, D. (2020) «Statins and Insulin Resistance», European cardiology, 15, S. e44. doi: 10.15420/ecr.2020.15.1.PO21.   
Panajatovic, M. V., Singh, F., Roos, N. J., Duthaler, U., Handschin, C., Krähenbühl, S. und Bouitbir, J. (2020) «PGC-1α plays a pivotal role in simvastatin-induced exercise impairment in mice», Acta physiologica (Oxford, England), 228(4), S. e13402. doi: 10.1111/apha.13402.   
Zhou, X., Bouitbir, J., Liechti, M. E., Krähenbühl, S. und Mancuso, R. V. (2020) «Para; -Halogenation of Amphetamine and Methcathinone Increases the Mitochondrial Toxicity in Undifferentiated and Differentiated SH-SY5Y Cells», International journal of molecular sciences, 21(8), S. 2841. doi: 10.3390/ijms21082841.   
Roos, N. J., Aliu, D., Bouitbir, J. und Krähenbühl, S. (2020) «Lapatinib Activates the Kelch-Like ECH-Associated Protein 1-Nuclear Factor Erythroid 2-Related Factor 2 Pathway in HepG2 Cells», Frontiers in pharmacology, 11, S. 944. doi: 10.3389/fphar.2020.00944.   
Roos, N. J., Duthaler, U., Bouitbir, J. und Krähenbühl, S. (2020) «The uricosuric benzbromarone disturbs the mitochondrial redox homeostasis and activates the NRF2 signaling pathway in HepG2 cells», Free radical biology & medicine, 152, S. 216-226. doi: 10.1016/j.freeradbiomed.2020.03.009.   
Zhou, X., Bouitbir, J., Liechti, M. E., Krähenbühl, S. und Mancuso, R. V. (2020) «Hyperthermia Increases Neurotoxicity Associated with Novel Methcathinones», Cells, 9(4), S. 965. doi: 10.3390/cells9040965.   
Bouitbir, J., Alshaikhali, A., Panajatovic, M., Abegg, V., Paech, F. und Krähenbühl, S. (2020) «Mechanisms of Cardiotoxicity Associated with Tyrosine Kinase Inhibitors in H9c2 Cells and Mice», European cardiology, 15, S. e33. doi: 10.15420/ecr.2020.15.1.PO10.   
Rudin, D., Schmutz, M., Roos, N. J., Bouitbir, J. und Krähenbühl, S. (2020) «Reactive Metamizole Metabolites Enhance the Toxicity of Hemin on the ATP Pool in HL60 Cells by Inhibition of Glycolysis», Biomedicines, 8(7), S. 212. doi: 10.3390/biomedicines8070212.   
Zhou, X., Luethi, D., Sanvee, G. M., Bouitbir, J., Liechti, M. E. und Krähenbühl, S. (2019) «Molecular Toxicological Mechanisms of Synthetic Cathinones on C2C12 Myoblasts», International journal of molecular sciences. Multidisciplinary Digital Publishing Institute, 20(7), S. 1561. doi: 10.3390/ijms20071561.   edoc
Bühler, T., Medinger, M., Bouitbir, J., Krähenbühl, S. und Leuppi-Taegtmeyer, A. (2019) «Hepatotoxicity Due to Azole Antimycotic Agents in a HLA B*35:02-Positive Patient», Frontiers in pharmacology. Frontiers Media, 10, S. 645. doi: 10.3389/fphar.2019.00645.   edoc
Bouitbir, J., Alshaikhali, A., Panajatovic, M. V., Abegg, V. F., Paech, F. und Krähenbühl, S. (2019) «Mitochondrial oxidative stress plays a critical role in the cardiotoxicity of sunitinib: Running title: Sunitinib and oxidative stress in hearts », Toxicology. Elsevier, 426, S. 152281. doi: 10.1016/j.tox.2019.152281.   edoc
Sanvee, G. M., Bouitbir, J. und Krähenbühl, S. (2019) «Insulin prevents and reverts simvastatin-induced toxicity in C2C12 skeletal muscle cells», Scientific reports. Nature Publishing Group, 9(1), S. 7409. doi: 10.1038/s41598-019-43938-5.   edoc
Sanvee, G. M., Panajatovic, M. V., Bouitbir, J. und Krähenbühl, S. (2019) «Mechanisms of insulin resistance by simvastatin in C2C12 myotubes and in mouse skeletal muscle», Biochemical pharmacology. Elsevier, 164, S. 23-33. doi: 10.1016/j.bcp.2019.02.025.   edoc
Singh, F., Zoll, J., Duthaler, U., Charles, A.-L., Panajatovic, M. V., Laverny, G., McWilliams, T. G., Metzger, D., Geny, B., Krähenbühl, S. und Bouitbir, J. (2019) «PGC-1β modulates statin-associated myotoxicity in mice», Archives of Toxicology. Springer, 93(2), S. 487-504. doi: 10.1007/s00204-018-2369-7.   edoc
Bouitbir, J., Sanvee, G. M., Panajatovic, M. V., Singh, F. und Krähenbühl, S. (2019) «Mechanisms of statin-associated skeletal muscle-associated symptoms», Pharmacological research. Elsevier, (154), S. 104201. doi: 10.1016/j.phrs.2019.03.010.   edoc
Malagnino, V., Duthaler, U., Seibert, I., Krähenbühl, S. und Meyer Zu Schwabedissen, H. E. (2019) «OATP1B3-1B7 (LST-3TM12) Is a Drug Transporter That Affects Endoplasmic Reticulum Access and the Metabolism of Ezetimibe», Molecular Pharmacology. American Society for Pharmacology and Experimental Therapeutics, 96(2), S. 128-137. doi: 10.1124/mol.118.114934.   edoc
Rudin, D., Lanzilotto, A., Bachmann, F., Housecroft, C. E., Constable, E. C., Drewe, J., Haschke, M. und Krähenbühl, S. (2019) «Non-immunological toxicological mechanisms of metamizole-associated neutropenia in HL60 cells», Biochemical Pharmacology. Elsevier, 163, S. 345-356. doi: 10.1016/j.bcp.2019.01.011.   edoc | Open Access
Mingard, C., Paech, F., Bouitbir, J. und Krähenbühl, S. (2018) «Mechanisms of toxicity associated with six tyrosine kinase inhibitors in human hepatocyte cell lines», Journal of applied toxicology : JAT. John Wiley And Sons, 38(3), S. 418-431. doi: 10.1002/jat.3551.   edoc
Paech, F., Mingard, C., Grünig, D., Abegg, V. F., Bouitbir, J. und Krähenbühl, S. (2018) «Mechanisms of mitochondrial toxicity of the kinase inhibitors ponatinib, regorafenib and sorafenib in human hepatic HepG2 cells», Toxicology. Elsevier, 395, S. 34-44. doi: 10.1016/j.tox.2018.01.005.   edoc
Paech, F., Abegg, V. F., Duthaler, U., Terracciano, L., Bouitbir, J. und Krähenbühl, S. (2018) «Sunitinib induces hepatocyte mitochondrial damage and apoptosis in mice», Toxicology. Elsevier, 409, S. 13-23. doi: 10.1016/j.tox.2018.07.009.   edoc
Berger, B., Bachmann, F., Duthaler, U., Krähenbühl, S. und Haschke, M. (2018) «Cytochrome P450 Enzymes Involved in Metoprolol Metabolism and Use of Metoprolol as a CYP2D6 Phenotyping Probe Drug», Frontiers in pharmacology, 9, S. 774. doi: 10.3389/fphar.2018.00774.   edoc
Grünig, D., Duthaler, U. und Krähenbühl, S. (2018) «Effect of Toxicants on Fatty Acid Metabolism in HepG2 Cells», Frontiers in pharmacology, 9, S. 257. doi: 10.3389/fphar.2018.00257.   edoc
Grünig, D., Felser, A., Duthaler, U., Bouitbir, J. und Krähenbühl, S. (2018) «Effect of the Catechol-O-Methyltransferase Inhibitors Tolcapone and Entacapone on Fatty Acid Metabolism in HepaRG Cells», Toxicological sciences. Oxford University Press, 164(2), S. 477-488. doi: 10.1093/toxsci/kfy101.   edoc
Bachmann, F., Duthaler, U., Rudin, D., Krähenbühl, S. und Haschke, M. (2018) «N-demethylation of N-methyl-4-aminoantipyrine, the main metabolite of metamizole», European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 120, S. 172-180. doi: 10.1016/j.ejps.2018.05.003.   edoc
Duthaler, U., Suenderhauf, C., Karlsson, M. O., Hussner, J., Meyer Zu Schwabedissen, H., Krähenbühl, S. und Hammann, F. (2018) «Population pharmacokinetics of oral ivermectin in venous plasma and dried blood spots in healthy volunteers», British journal of clinical pharmacology, 85(3), S. 626-633. doi: 10.1111/bcp.13840.   edoc
Duthaler, U., Berger, B., Erb, S., Battegay, M., Letang, E., Gaugler, S., Natamatungiro, A., Mnzava, D., Donzelli, M., Krähenbühl, S. und Haschke, M. (2018) «Using dried blood spots to facilitate therapeutic drug monitoring of antiretroviral drugs in resource-poor regions», Journal of Antimicrobial Chemotherapy. Oxford University Press, 73(10), S. 2729-2737. doi: 10.1093/jac/dky254.   edoc
Haegler, P., Grünig, D., Berger, B., Terracciano, L., Krähenbühl, S. und Bouitbir, J. (2017) «Hepatic Effects of Pharmacological Doses of Hydroxy-Cobalamin[c-lactam] in Mice», PLoS One. Public Library Science, 12(1), S. e0171026. doi: 10.1371/journal.pone.0171026.   edoc
Brueckner, D., Krähenbühl, S., Zuber, U., Bonkat, G. und Braissant, O. (2017) «An alternative sterility assessment for parenteral drug products using isothermal microcalorimetry», Journal of Applied Microbiology, 123(3), S. 773-779. doi: 10.1111/jam.13520.   edoc
Krähenbühl, S. und Pichler, W. J. (2017) «Medikamentöse Hepatopathien - Drug-induced liver injury», Therapeutische Umschau. Hogrefe, 74(3), S. 123-130. doi: 10.1024/0040-5930/a000895.   edoc
Paech, F., Bouitbir, J. und Krähenbühl, S. (2017) «Hepatocellular Toxicity Associated with Tyrosine Kinase Inhibitors: Mitochondrial Damage and Inhibition of Glycolysis», Frontiers in Pharmacology. Frontiers Media, 8, S. 367. doi: 10.3389/fphar.2017.00367.   edoc
Krähenbühl, S. (2017) «Importance of the skeletal muscle carnitine stores in fuel selection», The Journal of Physiology. Wiley, 595(17), S. 5727-5728. doi: 10.1113/JP274755.   edoc
Blaser, L., Hassna, H., Hofmann, S., Holbro, A., Haschke, M., Rätz Bravo, A., Zeller, A., Krähenbühl, S. und Taegtmeyer, A. (2017) «Leucopenia associated with metamizole: a case-control study», Swiss medical weekly. EMH Swiss Medical Publishers, 147, S. w14438. doi: 10.4414/smw.2017.14438.   edoc
Brueckner, D., Solokhina, A., Krähenbühl, S. und Braissant, O. (2017) «A combined application of tunable diode laser absorption spectroscopy and isothermal micro-calorimetry for calorespirometric analysis», Journal of Microbiological Methods. Elsevier, 139, S. 210-214. doi: 10.1016/j.mimet.2017.06.012.   edoc
Drago, S., Imboden, R., Schlatter, P., Buylaert, M., Krähenbühl, S. und Drewe, J. (2017) «Pharmacokinetics of Transdermal Etofenamate and Diclofenac in Healthy Volunteers», Basic and Clinical Pharmacology and Toxicology. Wiley, 121(5), S. 423-429. doi: 10.1111/bcpt.12818.   edoc
Grünig, D., Felser, A., Bouitbir, J. und Krähenbühl, S. (2017) «The catechol-O-methyltransferase inhibitors tolcapone and entacapone uncouple and inhibit the mitochondrial respiratory chain in HepaRG cells», Toxicology in Vitro. Elsevier, 42, S. 337-347. doi: 10.1016/j.tiv.2017.05.013.   edoc
Paech, F., Messner, S., Spickermann, J., Wind, M., Schmitt-Hoffmann, A.-H., Witschi, A. T., Howell, B. A., Church, R. J., Woodhead, J., Engelhardt, M., Krähenbühl, S. und Maurer, M. (2017) «Mechanisms of hepatotoxicity associated with the monocyclic β-lactam antibiotic BAL30072», Archives of Toxicology. Springer, 91(11), S. 3647-3662. doi: 10.1007/s00204-017-1994-x.   edoc
Haegler, P., Joerin, L., Krähenbühl, S. und Bouitbir, J. (2017) «Hepatocellular Toxicity of Imidazole and Triazole Antimycotic Agents», Toxicological sciences. Oxford University Press, 157(1), S. 183-195. doi: 10.1093/toxsci/kfx029.   edoc
Brueckner, D., Roesti, D., Zuber, U., Sacher, M., Duncan, D., Krähenbühl, S. und Braissant, O. (2017) «Tunable diode laser absorption spectroscopy as method of choice for non-invasive and automated detection of microbial growth in media fills», Talanta. Elsevier, 167, S. 21-29. doi: 10.1016/j.talanta.2017.01.088.   edoc