Aktuelle Masterarbeitsthemen der Forschungsgruppe Biopharmazie
Current Master's Theses-Projects of the Research Group in Biopharmacy
| Forschungsgebiet Research Field | Kontakt Betreuer/in Contact Supervisor | MSc Pharmazie | MSc Drug Sciences | Bemerkungen Comments |
|---|---|---|---|---|
| In the search of CYP2D6 biomarker: In-vitro metabolism of solanidine and other steroidal alkaloids | Dr. Marta Rysz | yes | no | This work will be conducted in the laboratory of the Biopharmacy research group at the University of Basel. Project description |
| The role of Pgp genotype in Blood-Brain-barrier permeability for antidepressant drugs | Dr. Marta Rysz | yes | no | This work will be conducted in the laboratory of the Biopharmacy research group at the University of Basel. Project description |
| Investigating the influence of age and transporter genotypes on coproporphyrin levels in healthy children | Leila Potzel | yes | yes | This work will be conducted in the laboratory of the Biopharmacy research group at the University of Basel. Project description |
| Investigating the influence of OATP1B1 genetic variants on coproporphyrin uptake in vitro | Leila Potzel | yes | yes | This work will be conducted in the laboratory of the Biopharmacy research group at the University of Basel. Project description |
| Investigating solanidine as a biomarker to study phenoconversion of CYP2D6 | Leila Potzel | yes | no | This is a multidisciplinary project between the Biopharmacy and the Pharmaceutical Care Research Groups. The experimental part of this work (incl. UHPLC-MS/MS and genotyping) will be performed in the Biopharmacy laboratory at the University of Basel. Project description |
| Breaking New Ground in Phenotyping: Solanidine Metabolism as a CYP2D6 Activity Indicator | Nikolaos Paloumpis | yes | no | This work will be conducted in the laboratory of the Biopharmacy research group at the University of Basel. Project description |
| Effects of clinically used drugs on heme biosynthesis in various blood cell types isolated from umbilical cord blood | Dr. Karin Brecht | yes | yes | This work will be conducted in the laboratory of the Biopharmacy research group at the University of Basel. Project description |
| Development of a Novel In Vitro Human Hepatocyte Model to Predict Drug Transport Alterations in Nonalcoholic Fatty Liver Disease (NAFLD) | Contact person: Dr. Jacqueline B. Tiley | yes | yes | This work will be conducted in the laboratories of the UNC Eshelman School of Pharmacy, USA |
| Optimization of Liver Organoid Culture Conditions to Improve Transport Protein Levels and Function | Contact person: Dr. Jacqueline B. Tiley | yes | yes | This work will be conducted in the laboratories of the UNC Eshelman School of Pharmacy, USA Project description |
| Optimization of Methods to Extract Transporter-Enriched Extracellular Vesicles from Various Biological Samples | Dr. Jacqueline B. Tiley | yes | yes | This work will be conducted in the laboratories of the UNC Eshelman School of Pharmacy, USA Project description |
| Use of Endogenous Transporter Substrate Coproporphyrin-I to Assess Transporter Drug Interactions (tDIs) in Vitro | Dr. Jacqueline B. Tiley | yes | yes | This work will be conducted in the laboratories of the UNC Eshelman School of Pharmacy, USA Project description |
| Light responsive approach to study NTCP regulation and function | Dr. Jacqueline B. Tiley | yes | yes | This work will be conducted in the laboratories of the UNC Eshelman School of Pharmacy, USA Project description |
| No longer available Effects of OATP1B inhibitors on erythropoiesis and heme biosynthesis of multipotent stem cells isolated from umbilical cord blood | Dr. Karin Brecht | yes | no | This work will be conducted in the laboratory of the Biopharmacy research group at the University of Basel. Project description |
| No longer available Influence of SLCO1B1 genotypes on coproporphyrin levels in healthy children | Leila Potzel | yes | no | This work will be conducted in the laboratory of the Biopharmacy research group at the University of Basel. Project description |
| No longer available OATP1B1 and statin tolerability – from genetic variation to drug interactions | Dr. Céline Stäuble | yes | no | This is a multidisciplinary project between the Biopharmacy and the Pharmaceutical Care Research Groups. The experimental part of this work (incl. UHPLC-MS/MS and genotyping) will be performed in the laboratory of the Biopharmacy research group at the University of Basel. Project description |
| No longer available Impact of pharmacogenetic testing on drug safety and efficacy in chronic pain patients | Anna Bollinger | yes | no | This is a multidisciplinary project between the Biopharmacy and the Pharmaceutical Care Research Groups. The project consists of the genotyping of polymorphisms in a clinical pain population (laboratory of the Biopharmacy) and a qualitative research project, in which those patients are interviewed (PCRG). |
| No longer available Natural product discovery pipeline to identify antidotes against amatoxin toxicity: Targeting OATP1B3-mediated uptake | Dr. Anima Schäfer | no | yes | This is a multidisciplinary project and the student will be supervised by both Anima Schäfer (Biopharmacy) and Eliane Garo (Pharmaceutical Biology). This project is therefore advertised in both groups. Project description |
| No longer available Investigation of OATP transporters localization and role at the Blood-Brain Barrier | Valerio Taggi | yes | no | In our project we will investigate the localization – apical and/or basolateral - of OATP transporters at the Blood-Brain Barrier and we will evaluate their role into the brain uptake of drugs and endogenous compounds. This work will be conducted in the laboratory of the Biopharmacy research group at the University of Basel. |
| No longer available Why does genetic modification of the drug uptake transporter OATP2B1 affect the expression of CYP3A in liver but not the in vivo metabolism of the CYP3A-phenotyping drug midazolam - a mechanistic study | Nikolaos Paloumpis | yes | no | This work will be conducted in the laboratory of the Biopharmacy research group at the University of Basel. Project description |
| No longer available Impact of long-term erlotinib treatment on intestinal CYP content and activity - a study comparing the data from Slco2b1 -/-vs hSLCO2B1 +/+ rats | Dr. Marta Rysz | yes | no | This work will be conducted in the laboratory of the Biopharmacy research group at the University of Basel. Project description |
| No longer available Investigation of the ethical and moral values underpinning decision-making and approval of animal experiments in Switzerland | Prof. Dr. Bernice Elger | yes | no | This work will be conducted at the Institute for Biomedical Ethics. Project description |
| No longer available Views on the implementation of 3R in Switzerland: a qualitative exploration | Prof. Dr. Bernice Elger | yes | no | This work will be conducted at the Institute for Biomedical Ethics. Project description |