Aktuelle Masterarbeitsthemen der Forschungsgruppe Molekulare Pharmazie
Current Master's Theses-Projects of the Research Group in Molecular Pharmacy
| Forschungsgebiet Research Field | Kontakt Betreuer/in Contact Supervisor | MSc Pharmazie | MSc Drug Sciences | Bemerkungen Comments |
|---|---|---|---|---|
| Protection of transplants and biomaterials from immune attack. Development of model systems and therapeutic strategies | Dr. Ekaterina Umnyakova | ja | ja | Project description |
| Application of 5C6 on artificial materials for the prevention of unintended complement activation and the purification of complement proteins from blood | Jannes Felsch | ja | ja | Project description |
| Cloning, expression, purification and evaluation of therapeutically relevant proteins involved in the modulation of immune and inflammatory responses. | PD Dr. Said Rabbani | ja | ja | Project description |
| Design and Development of New Peptide Conjugates based on Compstatin for Improved Pharmacokinetics | Dr. Alexander Lander Stephanie Vogt | ja | ja | Project description |
| Deconstructing Proteins for the Development of Non-natural Peptide Analogues with Complement Regulatory Activity | Dr. Alexander Lander | ja | ja | Project description |
| Towards a Closed Loop System for the Design, Synthesis and Evaluation of Peptide-Based Serine Protease Inhibitors | Prof. Dr. Daniel Ricklin | ja | ja | Cooperation with Computational Pharmacy group, Prof. Dr. Markus Lill |
| Development of Carbohydrate-based Mimics as Ligands for Complement-related Lectins | PD Dr. Oliver Schwardt | ja | ja | The research project involves design, synthesis, and in vitro evaluation in collaboration with PD Dr. Martin Smiesko and PD Dr. Said Rabbani. |
Synthesis & development of antibiotic carbohydrate-based molecules | Dr. Rachel Hevey Dr. Carmen Cori Calizaya | ja | ja | For external and internal students. |
| Protein expression & biological evaluation of therapeutically-relevant proteins that regulate virulence in pathogens | Dr. Rachel Hevey Dr. Alem Storani | ja | ja | For external and internal students. |
| Design, synthesis & evaluation of carbohydrate-based antagonists of host defense proteins | Dr. Rachel Hevey | ja | ja | For external and internal students. |
| Design, synthesis and in vitro evaluation of peptidic complement inhibitors of the compstatin family with improved target and species binding properties. | Stephanie Vogt | ja | ja | Project description |
| Phage Display against different complement components: For identification and development of novel peptide complement inhibitors | Stephanie Vogt | ja | ja | Project description For external and internal students. |
| no longer available Development of novel complement initiation inhibitors derived from parasites to attenuate immune response. | Aleksandra Blagojevic | Project description For external and internal students. | ||
| no longer available Protein Engineering of a Leech-Derived Protein | Dr. Peter Rüthemann | Project description | ||
no longer available | Dr. Peter Rüthemann | Project description | ||
| no longer available Preparation of protein-based targets and modulators of the innate immune system and their evaluation in bioassays. | PD Dr. Said Rabbani | |||
| no longer available Synthesis and biological evaluation of antiviral compounds | Dr. Butrint Aliu | ja | ja | |
| no longer available Synthesis and development of glycopolymers for treating blood group-incompatible transplantations | Dr. Rachel Hevey | ja | ja | Collaboration with University Start-up Polyneuron Pharmaceuticals AG |
| no longer available Evaluation of physiological or therapeutic immune modulators of the complement/coagulation system. | Dr. Richard Pouw | ja | ja | |
| no longer available In vitro assessment of glycopolymers for enabling blood group-incompatible transplantations | Dr. Rachel Hevey | ja | ja | Collaboration with University Start-up Polyneuron Pharmaceuticals AG |
no longer available | Prof. Dr. Daniel Ricklin | nein | ja | External master’s thesis with MOMM Diagnostics GmbH and FHNW. Preferred project start in August 2021 or earlier; first contact Prof. Dr. Daniel Ricklin |
| no longer available Removal of autoantibodies against glycans - Biological and biophysical characterization of autoantibody-glycopolymer complexes | Butrint Aliu | ja | ja | Collaboration with University Start-up Polyneuron Pharmaceuticals AG; |
| no longer available Novel Anti-Inflammatories: Identification of Selectin Antagonists by a Dynamic Combinatorial Chemistry Approach | Prof. em. Dr. Beat Ernst | ja | ja | preferred MSc Drug Sciences |
| no longer available Evaluation and Summarization Praktikum | PD Dr. Oliver Schwardt | ja | ja | |
no longer available | Prof. Dr. Daniel Ricklin | ja | ja | Collaboration with Universitätsspital Basel Project description |
| no longer available Establishment and validation of a Mannan-induced psoriasis arthritis-like disease model in mice | Prof. Dr. Daniel Ricklin | nein | ja | Masterthesis with Idorsia; first contact Prof. Dr. Daniel Ricklin |