Ligand - target interactions

Our research investigates enzymes controlling the access of ligands to their cognate receptors, with a major focus on short-chain dehydrogenase/reductase (SDR) enzymes and steroid hormone receptors. The following key questions are addressed:

Ligand binding to enzyme / receptor

Ø  Structure-function relationships
Ø  Selectivity of substrate/ligand binding
Ø  Species-specific differences
Ø  Functional biomarkers of enzyme activity

Receptor-mediated signaling

Ø  Mechanisms of receptor activation
Ø  Signaling pathways and interaction with other pathways
Ø  Consequences of receptor signaling in health and disease states
Ø  Functional biomarkers of receptor activity