Aktuelle Masterarbeitsthemen der Forschungsgruppe Pharmazeutische Biologie
Current Master's Theses-Projects of the Research Group in Pharmaceutical Biology
| Forschungsgebiet Research Field | Kontakt Betreuer/in Contact Supervisor | MSc Pharmazie | MSc Drug Sciences | Bemerkungen Comments |
|---|---|---|---|---|
No longer available Biosynthesis of bacterial tropone natural products | Prof. Robin Teufel | ja | ja | |
EFFECTS OF PROANTHOCYANIDINES on mitochondrial functionin neuronal cells Main working hypothesis: Based on previous data demonstrating an antioxidant activity of a proanthocyanidine (PAC) fraction from a Ginkgo biloba extract, we hypothesize that a treatment with PACs may have a beneficial impact on mitochondrial function of human neuroblastoma cells (SH-SY5Y cells). Specific aims: PACs will be tested in human neuroblastoma cells (SH-SY5Y cells) with regard to their efficiency in ameliorating cellular bioenergetics (ATP level) and mitochondrial membrane potential (MMP). | Prof. Anne Eckert | ja | Principal Investigator and working place: Professor Anne Eckert, PhD Psychiatric University Clinics (UPK Basel) Phone: 0041 61 325 5487 E-mail: anne.eckert@clutterupk.ch; anne.eckert@clutterunibas.ch Master thesis can be written in English or German | |
Bryophyllum pinnatum potential in the treatment of preterm contractions Pregnancy is a critical period for medical care, well-being of both the woman and the foetus are to be considered. In particular, the choice of – herbal and synthetic – medications to treat various disorders requires a careful risk/benefit evaluation. This is also the case for the treatment of preterm birth, defined as birth before 37 weeks of pregnancy, which is the number one cause of neonatal deaths, and the second leading cause of childhood death under 5 years of age. Standard treatment includes pharmacological inhibition of myometrial contractions. Several types of medications allow achieving a 24-48h delivery delay, which is of paramount clinical importance. Risk/benefit assessments show, however, that their longer use must be avoided despite the fact that pregnancy prolongation favours perinatal outcomes. Current research focus on alternative medications that are well-tolerated and positively affect additional relevant processes, e.g. inflammation. Bryophyllum pinnatum is a perennial succulent plant that grows widely in tropical and subtropical areas. In Europe, it started to be used in anthroposophic medicine as treatment of preterm labour in the 1970’s. Retrospective studies revealed good efficacy of B. pinnatum preparations in this indication and a very good tolerability of B. pinnatum, both aspects being required for long-term tocolysis. Experimental evidence shows that B. pinnatum (compounds) can inhibit myometrial contractility and associated signalling pathways. In this project, we want to investigate whether B. pinnatum (compounds) additionally affect inflammation-related pathways. | PD Dr. phil II Ana Paula Simões-Wüst | ja | Arbeitsort: PD Dr. phil II Ana Paula Simões-Wüst UniversitätsSpital Zürich Tel.: +41 44 255 51 31 | |
No longer available Zwischen Futter und Arznei - das Potential wirkstoffreicher Grünlandpflanzen der Alpenregion zur Steigerung der Resilienz von Wiederkäuern | Florian Leiber und Michael Walkenhorst | ja |
| |
No longer available Search for new Cas9 modulators in plant extracts | Prof. O. Potterat | ja | ||
No longer available Natural Product active on Musashi (MSI1) | Dr. E. Garo | ja | ||
No longer available Target Identification for MAPK and ERK pathway | Dr. E. Garo | ja | ja | |
No longer available Phytochemical profile and bioactive constituents of the stinking hellebore (Helleborus foetidus) | Prof. O. Potterat | ja | ||
No longer available Metabolite profiling of Hibiscol®, a food supplement containing chokeberry and hibiscus extracts | Prof. O. Potterat | Ja | Nein | |
No longer available Isolation of bufadienolides from Bryophyllum pinnatum and B. daigremontianum | Prof. O. Potterat | ja | nein | |
No longer available Identifying Natural products inhibiting the mTOR Complex1 (mTORC1) | Dr. E. Garo | ja | nein | |
No longer available Protective effects of polyamines and/or wheat germ extract on mitochondrial activity and viability in an Alzheimer’s disease cell culture model | Prof. Anne Eckert | ja |