Neue personalisierte Arzneimittel mittels 3D-Druck

Im pädiatrischen Bereich sind Arzneimitteldosierungen erforderlich, die am Pharmamarkt nicht zur Verfügung stehen. Diese Lücke versuchen wir mit der Herstellung personalisierter Arzneimittel über 3D-Druck zu füllen. Zusammen mit der FHNW und einer öffentlichen Apotheke entwickeln wir innovative, an die neue Technologie adaptierte Formulierungen, die alle Qualitätsanforderungen erfüllen. Wenn Sie Leidenschaft für pharmazeutische Technologie und moderne Systeme mitbringen, freuen wir uns sehr auf Unterstützung im Rahmen Ihrer Masterarbeit.

Dr. Uli Lösch

Dr. Uli Lösch

Wirksamkeit und Sicherheit von Serum autolog Augentropfen

Die Therapie mit Serum autologe Augentropfen ist bei extrem trockenen Augen oft die letzte Therapieoption. Da aussagekräftige prospektive Studien fehlen, sollen erste Daten zur Therapie von in der Schweiz mit Serum autolog Augentropfen behandelten Patienten strukturiert in einer neu zu erstellenden Datenbank erfasst, und dann hinsichtlich Wirksamkeit und Sicherheit bewertet werden.

Dr. Stefanie Deuster

Stefanie.Deuster@clutterusb.ch

Gender differences in pharmacoepidemiology

There are many medications where it is not known whether there is a difference between men and women in regards of drug safety, efficacy, and drug utilization. In this project you will work with real world data from Switzerland or the UK and use pharmacoepidemiologic methods to further investigate the influence of gender on medication. We especially focus on medication used in metabolic diseases such as diabetes mellitus type 2.

Georg Bailer

Georg Bailer

Dr. Cornelia Schneider

Dr. Cornelia Schneider

Antiemetics during pregnancy

In this master thesis, you will explore medication use during pregnancy using real-world data from Swiss health insurance records. Focusing on the use of antiemetics during pregnancy, the study aims to examine prescribing patterns and treatment prThe use of ADHD medications during pregnancy, an epidemiologic study using data of the Helsana claims database

In this master’s thesis you will investigate the use of ADHD medications during pregnancy using real-world data from Swiss health insurance records. It focuses on prescribing patterns and treatment prevalence in a population that remains underrepresented in research. With the rising number of ADHD diagnoses, also among adults, in recent years, it is of great public health importance to understanding medication use during pregnancy.evalence in a population often excluded from clinical trials. In recent years, novel treatment options have entered the market, making it particularly relevant to study how these therapies are being adopted in clinical practice.

Sarah Ommerli

Sarah Ommerli

Dr. Julia Spoendlin

Dr. Julia Spoendlin

An epidemiologic study to evaluate suitability of the FIVNAT database to evaluate women with endometriosis undergoing assisted reproduction procedures. 

In this master thesis you will evaluate women with endometriosis who are captured in the FIVNAT database and who are undergoing assisted reproduction procedures (ART). The FIVNAT database captures data from all clinics offering ART in Switzerland, but has not been used much for epidemiologic research so far. This master thesis will help to evaluate suitability of this database for further research projects.

Dr. Julia Spoendlin

Dr. Julia Spoendlin

Outpatient antibiotic prescribing in early life: Analysis of primary care data from the UK

A previous study analyzed antibiotic prescriptions for children aged 0 to 2 years in Denmark and Germany. Compared to Denmark, children in Germany had their first antibiotic drug later in life and received fewer antibiotic drugs. However, the German children were prescribed more problematic antibiotic drugs (according to a WHO classification). We are currently analyzing Claims data from Switzerland and plan to conduct similar analyses in a pediatric population from the UK to compare the results to the previous study. The Master thesis involves participation in the setting up of the (pharmacoepidemiologic) study design, creation of drug code lists, statistical analysis of the data and compilation of the thesis.

Dr. Claudia Becker

Dr. Claudia Becker

Anwendung von Inhalativa bei geriatrischen Patientinnen und Patienten

Bei COPD-Patienten, welche in der Universitäre Altersmedizin FELIX PLATTER hospitalisiert sind, soll überprüft werden, ob sie ihre Inhalativa korrekt anwenden. Im Falle einer nicht korrekten Anwendung sollen Massnahmen wie patienten-spezifische Schulung und ggf. Präparatwechsel getroffen und deren Wirkung überprüft werden.

Dr. Luzia Renggli

Luzia.Renggli@clutterusb.ch

Analysis and Assessment of Adherence to Guidelines for Vancomycin Therapeutic Drug Monitoring

Appropriate use of antibiotics is essential to limit the development of antimicrobial resistance. This master’s thesis will retrospectively analyze vancomycin prescriptions and therapeutic drug monitoring in patients hospitalized at the USB and will focus on adherence to guidelines regarding plasma level measurements, as well as the proportion of patients who achieve target levels. Additionally, it aims to identify factors associated with failing to reach these target levels.

Andrea Studer

Andrea.Studer@clutterusb.ch

Dr. Cornelia Schneider

Cornelia.Schneider@clutterusb.ch

Medication use in menopause

Menopause is a period of major hormonal changes that may influence the onset of new diseases, such as metabolic dysfunction–associated steatotic liver disease (MASLD)—the most common chronic liver disease worldwide—leading to the initiation of new pharmacological treatments. However, medication use in this population remains largely underexplored. This master’s thesis aims to investigate medication use among menopausal women and their male counterparts (i.e., men in the same age range), with a focus on overall medication use, polypharmacy (≥5 medications), menopausal hormone therapy, and “liver-sensitive” medications. To address these objectives, we will leverage real-world data from Swiss health insurance records.

Dr. Carole Marxer

carole.marxer@clutterki.se

Polypharmacy and medication use in and after pregnancy

In Switzerland, more than 85% of pregnant women take at least one medication during pregnancy, with 33% taking more than five, indicating polypharmacy. Similar patterns are observed in the postpartum period, when many women breastfeed. However, several questions remain regarding (1) polypharmacy (e.g., which drug combinations are most prevalent), (2) the initiation of pharmacological treatments after pregnancy (e.g., the increasing use of GLP-1 receptor agonists for postpartum weight gain, as shown in a Danish study), and (3) whether medications used in the postpartum period in Switzerland are considered safe. This master’s thesis aims to address these questions at the intersection of the pregnancy and breastfeeding periods using real-world data from Swiss health insurance records.

Dr. Carole Marxer

carole.marxer@clutterki.se