Aktuelle Masterarbeitsthemen der Forschungsgruppe Molekulare Pharmazie
Current Master's Theses-Projects of the Research Group in Molecular Pharmacy

 

Forschungsgebiet
Research Field
Kontakt Betreuer/in
Contact Supervisor
MSc PharmazieMSc Drug SciencesBemerkungen
Comments
Protection of transplants and biomaterials from immune attack. Development of model systems and therapeutic strategiesDr. Ekaterina UmnyakovayesyesProject description
Application of 5C6 on artificial materials for the prevention of unintended complement activation and the purification of complement proteins from bloodJannes FelschyesyesProject description
Cloning, expression, purification and evaluation of therapeutically relevant proteins involved in the modulation of immune and inflammatory responses.PD Dr. Said RabbaniyesyesProject description
Deconstructing Proteins for the Development of Non-natural Peptide Analogues with Complement Regulatory ActivityDr. Alexander LanderyesyesProject description
Towards a Closed Loop System for the Design, Synthesis and Evaluation of Peptide-Based Serine Protease InhibitorsProf. Dr. Daniel RicklinyesyesCooperation with Computational Pharmacy group, Prof. Dr. Markus Lill
Development of Carbohydrate-based Mimics as Ligands for Complement-related LectinsPD Dr. Oliver SchwardtyesyesThe research project involves design, synthesis, and in vitro evaluation in collaboration with PD Dr. Martin Smiesko and PD Dr. Said Rabbani.

Synthesis & development of antibiotic carbohydrate-based molecules

Dr. Rachel Hevey
Dr. Carmen Cori Calizaya
yesyesFor external and internal students.
Protein expression & biological evaluation of therapeutically-relevant proteins that regulate virulence in pathogensDr. Rachel Hevey
Dr. Alem Storani
yesyesFor external and internal students.
Design, synthesis & evaluation of carbohydrate-based antagonists of host defense proteinsDr. Rachel HeveyyesyesFor external and internal students.
Phage Display against different complement components: For identification and development of novel peptide complement inhibitorsStephanie VogtyesyesProject description
For external and internal students.
     
no longer available
Small Molecule Drug Development: Bridging Computational and Experimental Approaches

Dr. Peter Rüthemann
Prof. Dr. Martin Smieško

  Project description
Cooperation with Computational Pharmacy goup.
no longer available
Protein Engineering of a Leech-Derived Therapeutic Protein
Dr. Peter Rüthemann  Project description
 
no longer available
Design and Development of New Peptide Conjugates based on Compstatin for Improved Pharmacokinetics
Dr. Alexander Lander
Stephanie Vogt
  Project description
no longer available
Design, synthesis and in vitro evaluation of peptidic complement inhibitors of the compstatin family with improved target and species binding properties.
Stephanie Vogt  Project description
no longer available
Development of novel complement initiation inhibitors derived from parasites to attenuate immune response.
Aleksandra Blagojevic  Project description
For external and internal students.
no longer available
Protein Engineering of a Leech-Derived Protein
Dr. Peter Rüthemann  Project description
 

no longer available
Protein engineering for the development of parasite-derived inhibitors of the complement system. Projects include immunogenicity analysis, characterisation of post-translational modifications and protein expression.

Dr. Peter Rüthemann  Project description
no longer available
Preparation of protein-based targets and modulators of the innate immune system and their evaluation in bioassays.
PD Dr. Said Rabbani   
no longer available
Synthesis and biological evaluation of antiviral compounds
Dr. Butrint Aliu   
no longer available
Synthesis and development of glycopolymers for treating blood group-incompatible transplantations
Dr. Rachel Hevey  Collaboration with University Start-up Polyneuron Pharmaceuticals AG
no longer available
Evaluation of physiological or therapeutic immune modulators of the complement/coagulation system.
Dr. Richard Pouw   
no longer available
In vitro assessment of glycopolymers for enabling blood group-incompatible transplantations
Dr. Rachel Hevey  Collaboration with University Start-up Polyneuron Pharmaceuticals AG

no longer available
Point-of-Care-Diagnostics for Preeclampsia (Development of sensitive, antibody-based in-vitro diagnostic rapid tests)

Prof. Dr. Daniel Ricklin  External master’s thesis with MOMM Diagnostics GmbH and FHNW. Preferred project start in August 2021 or earlier;
first contact Prof. Dr. Daniel Ricklin
no longer available
Removal of autoantibodies against glycans - Biological and biophysical characterization of autoantibody-glycopolymer complexes
Butrint Aliu  Collaboration with University Start-up Polyneuron Pharmaceuticals AG; 
no longer available
Novel Anti-Inflammatories: Identification of Selectin Antagonists by a Dynamic Combinatorial Chemistry Approach
Prof. em. Dr. Beat Ernst  preferred MSc Drug Sciences
no longer available
Evaluation and Summarization Praktikum
PD Dr. Oliver Schwardt   

no longer available
Development of a new class of radiopharmaceuticals for diagnosis and therapy of CXCR4-expressing malignancies

Prof. Dr. Daniel Ricklin  Collaboration with Universitätsspital Basel
Project description
no longer available
Establishment and validation of a Mannan-induced psoriasis arthritis-like disease model in mice
Prof. Dr. Daniel Ricklin  Masterthesis with Idorsia; first contact Prof. Dr. Daniel Ricklin