Aktuelle Masterarbeitsthemen der Forschungsgruppe Pharmazeutische Technologie
Current Master's Theses-Projects of the Research Group in Pharmaceutical Technology
|MSc Drug Sciences
Wir können eine Masterarbeit in Zusammenarbeit mit Partnern der Universität Toyama in Japan anbieten: https://www.u-toyama.ac.jp/en/outline/.
Die Arbeit wird in Japan durchgeführt und durch dortige Wissenschaftler begleitet. Verschiedene Themen werden angeboten in Fachgebieten der Pharmazeutische Biologie, Pharmakologie und Technologie.
|Prof. Jörg Huwyler
Screening of lipid nanoparticles for DNA gene delivery
In recent years, there has been significant interest in employing lipid nanoparticles (LNPs) for RNA delivery, with numerous candidates progressing through clinical pipelines as potential vaccines or therapies for diverse diseases. Microfluidics presents notable advantages for LNP production, owing to its scalability, reproducibility, and rapid preparation. This study aims to assess operational and formulation parameters crucial for LNP development. We will investigate various lipids, including ionizable and helper lipids, examining their physicochemical properties and conducting in vitro experiments.
|Evrim Ümit Kuzucu
|Development of sustained release gel formulations to treat onychomycosis after laser poration of nails
|University of Geneva
Formulation development of recombinant adeno-associated viruses used as gene delivery systems
The pharmaceutical market is currently transforming and advanced medicinal products (ATMPs) are entering the market. These comprise among others delivery systems such as viral vectors and specifically include recombinant adeno associated virus (rAAVs).
However, clinical and commercial rAAV products are currently stored at frozen state (e.g., -80°C) due to their limited stability when stored under refrigerated conditions for extended periods. For instance, Luxturna® and Zolgensma® are stored at -80 °C and their shelf-life is still limited to a duration of one year.
The aim of the Master thesis is to develop a formulation platform for rAAV products enabling storage at 2-8°C omitting the costly freeze/thaw supply chain, while maintaining product integrity, purity and effectiveness. The formulation platform will comprise a screening system capable of evaluating diverse combinations of viral vector concentrations, of suitable stabilizing excipients including pH/buffer systems, and other variables that influence the stability of rAAV products. The project will use various established analytical techniques including cell culture experiments to test the formulations.
The Master thesis project will start in Apil 2024 with a duration of 8-12 months in cooperation with the pharmaceutical company ten23 health.
Experiments will be performed both at the University of Basel (Pharmazentrum) as well as at the ten23’s labs at Rosenthal campus (Mattenstr. 22) in Basel.
|ten23 health AG
Design and evaluation of specific coated capsule formulation for delivery of live bacteria in the colon
The main goal of the thesis will be designing specific film-coated capsule formulation aiming to deliver appropriate amount of viable bacterial cells in the colonic region. Different coating compositions aimed for colon targeting should be evaluated together with finding the optimal coating parameters which will not cause significant loss in cell viability. Fit-for-purpose techniques such as blending and encapsulation followed by pan coating will be used for producing the desired prototype formulations. Obtained prototypes are going to be evaluated through various in-vitro techniques predicting the in-vivo behavior such as: disintegration (compendial and bio-relevant), dissolution (compendial and bio-relevant), media-uptake as well as different techniques predicting their processibility (flow properties, particle size distribution, bulk/tap volume/density), stability (water content and water activity) and mechanical resistance. Cell enumeration will be done through different techniques (CFU, MPN, etc) in collaboration with Bacthera’s development site in Denmark.
|Bacthera AG Basel
Theoretical Master’s Thesis in Pharmaceutical Development (8 months)
The theoretical Master thesis will conduct research at the interface between pharmaceutical drug product manufacturing of biologics and sustainability considerations. As Master’s thesis candidate, you will actively participate in critical scientific research to develop solutions for real-world pharmaceutical & clinical problems benefitting the patients and caregivers. You will be guided by one of our experts to contribute to various aspects and challenges of Pharmaceutical development. You are expected to devote time for scientific literature reading and to produce/write self-review documents that would support your dissertation process. For further information please read here.
|Ms. Amrith Kiran
Master’s Thesis in Pharmaceutical Development (8 months)
As our Masters’ Student you will actively participate in critical scientific research to develop solutions for real-world pharmaceutical & clinical problems benefitting the patients and caregivers. You will be guided by one of our experts to contribute to various aspects and challenges of pharmaceutical development. The role will predominantly include laboratory work with commitment of time and effort for the project. You are also expected to devote time for scientific literature reading and to produce/write self-review documents that would support your dissertation process. For further information please read here.
|Ms. Amrith Kiran
|Optimierung einer pflanzlichen sprühbaren Emulsion zur Wundbehandlung (Resina Laricis / Lysimachia comp.)
|Society for Cancer Research, Arlesheim
Manufacture of drug loaded particles applying hot melt technology
In a first approach (highly) drug loaded multiparticulates will be developed, applying hot melt coating technologies. Alternatively, a development of tablets could be possible.
|Glatt Pharmaceutical Services GmbH & Co. KG
|Process optimization with a focus on hot-melt extrusion
|AbbVie Deutschland GmbH & Co.KG