Current Master 's Theses-Projects of the Research Group Translational Complementary Medicine
Current Master's Theses-Projects of the Research Group Translational Complementary Medicine
| Research Field Research Field | Contact Supervisor Contact Supervisor | MSc Pharmacy | MSc Drug Sciences | Comments Comments |
|---|---|---|---|---|
| Discovery and pharmacological analysis of cysteine-stabilized plant peptides (Execution: Vienna, Austria) The research focuses on the chemical analysis and pharmacology of cyclic cystine-knot plant peptides. These so called cyclotides are extremely stable molecules and hence ideally suited for oral drug delivery or as oral drug candidates. To warrant further pharmaceutical development of those peptides it is crucial to characterize their molecular structure and pharmacological activity. The aim of the master thesis is to identify and characterize cyclotides from different plant species using state-of-the-art HPLC and MS methodology and to analyze these peptides in a pharmacological context as to their function as ligands of G protein-coupled receptors (Muratspahic et al., Trends in Pharmacological Sciences, 2019). Contact: christian.w.gruber@cluttermeduniwien.ac.at http://www.meduniwien.ac.at/pharmakologie/ms/ | Prof. Carsten Gründemann | yes | no | |
| no longer available Samples from serum and plasma droplets dried in changing relative humidity More information about this external master thesis at the Association for Cancer Research (Arlesheim, CH) can be found here. Please contact PD Dr. Stephan Baumgartner St.Baumgartner@cluttervfk.ch | Prof. Carsten Gründemann | yes | no | |
no longer available Peripheral blood mononuclear cells (PBMCs) from healthy donors are incubated with different stimuli at different temperatures in vitro. The cells will be examined for their proliferation rate, subset of cell type populations, cytokine production and general immunomodulatory effects. | Prof. Carsten Gründemann | yes | yes | |
no longer available Different types of plant extracts and/or their ingredients are used in vitro on meibomian gland or corneal cells to study their cytotoxicity, wound healing and reactive oxygen species (ROS) reduction properties against different ROS inducers as well as to identify their secreted cytokines and the effects of each extract on immune cells. | Prof. Carsten Gründemann | yes | yes | |
no longer available Human immune cells from healthy donors are exposed to different plant extracts. The extracts will be investigated and characterized for their immunomodulatory properties using different assay methods. | Prof. Carsten Gründemann | yes | no | |
no longer available In the context of earlier master theses at the University of Basel, formulations of a cream and a sprayable emulsion for the treatment of exulcerating tumors were evaluated and further developed. The formulation originates from the field of anthroposophic medicine and is based in particular on larch resin as well as extracts of thyme and pennywort (Lysimachia nummulariaL.). Initial applications in practice showed promising results (including pain relief, odor reduction, reduction of lesion size, promotion of wound closure). To determine the principle of action, dhe hydrophilic herbal active ingredients were iin cell culture were tested; cytotoxic cytotoxic and cytostatic effects were observed. The aim of the present master's thesis is to determine in cell culture experiments the fat-soluble components of Resina Laricis and thyme oil for cytotoxic and cytostatic effects in cell culture experiments. Contact: PD Dr. Stephan Baumgartner | Prof. Carsten Gründemann | yes | no |